Percutaneous cardiac recirculation-mediated gene transfer of an inhibitory phospholamban peptide reverses advanced heart failure in large animals.
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CPU86017, a berberine derivative, attenuates cardiac failure through normalizing calcium leakage and downregulated phospholamban and exerting antioxidant activityNovel role of phosphodiesterase inhibitors in the management of end-stage heart failureModel-specific selection of molecular targets for heart failure gene therapyProspects for gene transfer for clinical heart failureGene delivery technologies for cardiac applicationsCardiovascular gene therapy for myocardial infarctionGene therapy targets in heart failure: the path to translationCalcium mishandling in diastolic dysfunction: mechanisms and potential therapiesTargets for therapy in sarcomeric cardiomyopathiesStructure and topology of monomeric phospholamban in lipid membranes determined by a hybrid solution and solid-state NMR approachMybpc3 gene therapy for neonatal cardiomyopathy enables long-term disease prevention in miceMolecular targets in heart failure gene therapy: current controversies and translational perspectivesAAV-mediated gene therapy for heart failure: enhancing contractility and calcium handlingMYBPC3 in hypertrophic cardiomyopathy: from mutation identification to RNA-based correctionMyocardial gene transfer: routes and devices for regulation of transgene expression by modulation of cellular permeabilityHeart failure management: the present and the future.Anti-inflammatory loaded poly-lactic glycolic acid nanoparticle formulations to enhance myocardial gene transfer: an in-vitro assessment of a drug/gene combination therapeutic approach for direct injection.Targeted gene-silencing reveals the functional significance of myocardin signaling in the failing heartDiscovery and structural characterization of a phospholamban-binding cyclic peptide and design of novel inhibitors of phospholamban.Neonatal gene transfer of Serca2a delays onset of hypertrophic remodeling and improves function in familial hypertrophic cardiomyopathy.Rescuing the failing heart by targeted gene transferAltered myocardial calcium cycling and energetics in heart failure--a rational approach for disease treatment.Phospholamban phosphorylation, mutation, and structural dynamics: a biophysical approach to understanding and treating cardiomyopathy.Cardiac gene transfer of short hairpin RNA directed against phospholamban effectively knocks down gene expression but causes cellular toxicity in canines.Percutaneous transendocardial delivery of self-complementary adeno-associated virus 6 achieves global cardiac gene transfer in canines.Targeting cardiomyocyte Ca2+ homeostasis in heart failure.Phospholamban Ablation Using CRISPR/Cas9 System Improves Mortality in a Murine Heart Failure Model.Protein-protein interactions in calcium transport regulation probed by saturation transfer electron paramagnetic resonance.Tuning the structural coupling between the transmembrane and cytoplasmic domains of phospholamban to control sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) function.Potential of gene therapy as a treatment for heart failureLiquid jet delivery method featuring S100A1 gene therapy in the rodent model following acute myocardial infarction.Gene targeting in ischemic heart disease and failure: translational and clinical studies.Gene transfer for congestive heart failure: update 2013.Current strategies for myocardial gene delivery.Gene therapy in heart failure.Toward biologically targeted therapy of calcium cycling defects in heart failure.Remodeling of calcium handling in human heart failure.Myocardial repair: from salvage to tissue reconstruction.Targeting calcium handling in arrhythmias.Cell therapies for therapeutic angiogenesis: back to the bench.
P2860
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P2860
Percutaneous cardiac recirculation-mediated gene transfer of an inhibitory phospholamban peptide reverses advanced heart failure in large animals.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Percutaneous cardiac recircula ...... eart failure in large animals.
@en
Percutaneous cardiac recircula ...... eart failure in large animals.
@nl
type
label
Percutaneous cardiac recircula ...... eart failure in large animals.
@en
Percutaneous cardiac recircula ...... eart failure in large animals.
@nl
prefLabel
Percutaneous cardiac recircula ...... eart failure in large animals.
@en
Percutaneous cardiac recircula ...... eart failure in large animals.
@nl
P2093
P1476
Percutaneous cardiac recircula ...... eart failure in large animals.
@en
P2093
Arthur Preovolos
David M Kaye
John M Power
Justin A Mariani
Kenneth R Chien
Masahiko Hoshijima
Melissa Byrne
Roger Hajjar
Salvatore Pepe
Tanneale Marshall
P304
P356
10.1016/J.JACC.2007.03.047
P407
P577
2007-06-29T00:00:00Z