Erythropoietin gene therapy leads to autoimmune anemia in macaques.
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HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaquesGene therapy by electroporation for the treatment of chronic renal failure in companion animalsTransgene expression levels determine the immunogenicity of transduced hematopoietic grafts in partially myeloablated mice.PiggyBac transposon-based inducible gene expression in vivo after somatic cell gene transfer.Mesenchymal stromal cells engineered to express erythropoietin induce anti-erythropoietin antibodies and anemia in allorecipientsEvaluation of a rapamycin-regulated serotype 2 adeno-associated viral vector in macaque parotid glandsA lentiviral gene therapy strategy for the in vitro production of feline erythropoietin.Transgene detection by digital droplet PCRGeneration and in vivo evaluation of IL10-treated dendritic cells in a nonhuman primate model of AAV-based gene transferRegional intravascular delivery of AAV-2-F.IX to skeletal muscle achieves long-term correction of hemophilia B in a large animal modelIncreased erythropoiesis in mice injected with submicrogram quantities of pseudouridine-containing mRNA encoding erythropoietin.A concise peer into the background, initial thoughts and practices of human gene therapy.Genetic doping and health damages.Progress toward a nonviral gene therapy protocol for the treatment of anemia.Biochemistry, physiology, and complications of blood doping: facts and speculation.Immune responses to AAV vectors: overcoming barriers to successful gene therapyImmunity to adeno-associated virus vectors in animals and humans: a continued challenge.Gene doping: the hype and the reality.Distinct immune responses to transgene products from rAAV1 and rAAV8 vectorsAdministration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge.Vascular delivery of rAAVrh74.MCK.GALGT2 to the gastrocnemius muscle of the rhesus macaque stimulates the expression of dystrophin and laminin α2 surrogates.Novel adeno-associated virus vector vaccine restricts replication of simian immunodeficiency virus in macaques.From gene engineering to gene modulation and manipulation: can we prevent or detect gene doping in sports?Renal anemia: from incurable to curable.Gene replacement therapy for genetic hepatocellular jaundice.mRNA transcript therapy.The Skeletal Muscle Environment and Its Role in Immunity and Tolerance to AAV Vector-Mediated Gene Transfer.Equine performance genes and the future of doping in horseracing.Lack of immunotoxicity after regional intravenous (RI) delivery of rAAV to nonhuman primate skeletal muscle.Identification of a therapeutic dose of continuously delivered erythropoietin in the eye using an inducible promoter system.Muscle Gene Therapy for Hemophilia.Unraveling the complex story of immune responses to AAV vectors trial after trial.Measuring immune responses to recombinant AAV gene transfer.There must be a way out of here: identifying a safe and efficient combination of promoter, transgene, and vector backbone for gene therapy of neurological disease.Death switch for gene therapy: application to erythropoietin transgene expression.Transgene expression levels and kinetics determine risk of humoral immune response modeled in factor IX knockout and missense mutant mice.Long-term expression and repeated administration of AAV type 1, 2 and 5 vectors in skeletal muscle of immunocompetent adult mice.Minimal doses of a sequence-optimized transgene mediate high-level and long-term EPO expression in vivo: challenging CpG-free gene design.Longevity of rAAV vector and plasmid DNA in blood after intramuscular injection in nonhuman primates: implications for gene doping.Salivary glands and gene therapy: the mouth waters.
P2860
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P2860
Erythropoietin gene therapy leads to autoimmune anemia in macaques.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Erythropoietin gene therapy leads to autoimmune anemia in macaques.
@en
Erythropoietin gene therapy leads to autoimmune anemia in macaques.
@nl
type
label
Erythropoietin gene therapy leads to autoimmune anemia in macaques.
@en
Erythropoietin gene therapy leads to autoimmune anemia in macaques.
@nl
prefLabel
Erythropoietin gene therapy leads to autoimmune anemia in macaques.
@en
Erythropoietin gene therapy leads to autoimmune anemia in macaques.
@nl
P2093
P1433
P1476
Erythropoietin gene therapy leads to autoimmune anemia in macaques.
@en
P2093
Beth McCullough
Corinna Lebherz
Guangping Gao
James M Wilson
Rebecca Grant
Roberto Calcedo
P304
P356
10.1182/BLOOD-2003-11-3852
P407
P577
2003-12-24T00:00:00Z