Familial discrepancy between the one-stage and two-stage factor VIII methods in a subgroup of patients with haemophilia A.
about
Molecular defects in coagulation Factor VIII and their impact on Factor VIII function.A subset of high-titer anti-factor VIII A2 domain antibodies is responsive to treatment with factor VIII.Generation of enhanced stability factor VIII variants by replacement of charged residues at the A2 domain interface.New approaches in the measurement of coagulation.Specific and global coagulation assays in the diagnosis of discrepant mild hemophilia AChromogenic factor VIII activity assay.Assay discrepancy in mild haemophilia A.One-stage vs. chromogenic assays in haemophilia A.A critical appraisal of one-stage and chromogenic assays of factor VIII activity.Recombinant to modified factor VIII and factor IX - chromogenic and one-stage assays issues.Identification of residues contributing to A2 domain-dependent structural stability in factor VIII and factor VIIIaCombining mutations of charged residues at the A2 domain interface enhances factor VIII stability over single point mutationsStabilizing interactions between D666-S1787 and T657-Y1792 at the A2-A3 interface support factor VIIIa stability in the blood clotting pathway.Diagnosis and management challenges in patients with mild haemophilia A and discrepant FVIII measurements.Assaying FVIII activity: one method is not enough, and never was.Prevalence, biological phenotype and genotype in moderate/mild hemophilia A with discrepancy between one-stage and chromogenic factor VIII activity.Discrepancies between the one-stage clotting assay and the chromogenic assay in haemophilia B.Thrombin generation assay using factor IXa as a trigger to quantify accurately factor VIII levels in haemophilia A.Chromogenic Factor VIII Assays for Improved Diagnosis of Hemophilia A.p.Tyr365Cys change in factor VIII: haemophilia A, but not as we know it.Milder clinical presentation of haemophilia A with severe deficiency of factor VIII as measured by one-stage assay.Site and type of mutations in the factor VIII gene in patients and carriers of haemophilia A.Guidelines for the management of hemophilia.Single-dose pharmacokinetics of porcine factor VIII (Hyate C).Method validation and clinical utility of chromogenic factor VIII assay compared to one-stage assay.Enhanced factor VIIIa stability of A2 domain interface variants results from an increased apparent affinity for the A2 subunit. Results from an increased apparent affinity for the A2 subunit.
P2860
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P2860
Familial discrepancy between the one-stage and two-stage factor VIII methods in a subgroup of patients with haemophilia A.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年学术文章
@wuu
1994年学术文章
@zh
1994年学术文章
@zh-cn
1994年学术文章
@zh-hans
1994年学术文章
@zh-my
1994年学术文章
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1994年學術文章
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1994年學術文章
@zh-hant
name
Familial discrepancy between t ...... f patients with haemophilia A.
@en
Familial discrepancy between t ...... f patients with haemophilia A.
@nl
type
label
Familial discrepancy between t ...... f patients with haemophilia A.
@en
Familial discrepancy between t ...... f patients with haemophilia A.
@nl
prefLabel
Familial discrepancy between t ...... f patients with haemophilia A.
@en
Familial discrepancy between t ...... f patients with haemophilia A.
@nl
P2093
P921
P1476
Familial discrepancy between t ...... f patients with haemophilia A.
@en
P2093
P304
P356
10.1111/J.1365-2141.1994.TB06749.X
P407
P577
1994-08-01T00:00:00Z