Pharmacokinetics and pharmacodynamics of a new recombinant FVIII (N8) in haemophilia A mice.
about
A novel B-domain O-glycoPEGylated FVIII (N8-GP) demonstrates full efficacy and prolonged effect in hemophilic mice models.IL-6 receptor antagonist as adjunctive therapy with clotting factor replacement to protect against bleeding-induced arthropathy in hemophiliaPharmacokinetics and pharmacodynamics of SCT800, a new recombinant FVIII, in hemophilia A mice.Safety, Stability and Pharmacokinetic Properties of (super)Factor Va, a Novel Engineered Coagulation Factor V for Treatment of Severe Bleeding.Allometry of factor VIII and informed scaling of next-generation therapeutic proteins.Pharmacokinetics and pharmacodynamics of turoctocog alfa and N8-GP in haemophilia A dogsNonlinear pharmacokinetics of factor VIII and its phosphatidylinositol lipidic complex in hemophilia A mice.Allometric scaling and prediction of concentration-time profiles of coagulation factors in humans from animals.Designing first-in-human dose of coagulation factors: application of pharmacokinetic allometric scaling.Turoctocog alfa (NovoEight®)--from design to clinical proof of concept.Turoctocog alfa for the treatment of hemophilia a.Turoctocog alfa: an evidence-based review of its potential in the treatment of hemophilia AHigh-affinity von Willebrand factor binding does not affect the anatomical or hepatocellular distribution of factor VIII in rats.Development of a tail vein transection bleeding model in fully anaesthetized haemophilia A mice - characterization of two novel FVIII molecules.A sensitive venous bleeding model in haemophilia A mice: effects of two recombinant FVIII products (N8 and Advate(®)).Recombinant human prothrombin (MEDI8111) prevents bleeding in haemophilia A and B mice.The F8(-/-) rat as a model of hemophilic arthropathy.Gene Therapy with BMN 270 Results in Therapeutic Levels of FVIII in Mice and Primates and Normalization of Bleeding in Hemophilic Mice.
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P2860
Pharmacokinetics and pharmacodynamics of a new recombinant FVIII (N8) in haemophilia A mice.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
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2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh-hant
name
Pharmacokinetics and pharmacod ...... II (N8) in haemophilia A mice.
@en
Pharmacokinetics and pharmacodynamics of a new recombinant FVIII
@nl
type
label
Pharmacokinetics and pharmacod ...... II (N8) in haemophilia A mice.
@en
Pharmacokinetics and pharmacodynamics of a new recombinant FVIII
@nl
prefLabel
Pharmacokinetics and pharmacod ...... II (N8) in haemophilia A mice.
@en
Pharmacokinetics and pharmacodynamics of a new recombinant FVIII
@nl
P2093
P2860
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P1476
Pharmacokinetics and pharmacod ...... II (N8) in haemophilia A mice.
@en
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M Tranholm
P2860
P304
P356
10.1111/J.1365-2516.2011.02608.X
P577
2011-07-19T00:00:00Z