Generation of bidirectional hypoxia/HIF-responsive expression vectors to target gene expression to hypoxic cells.
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In silico structural and functional characterization of the RSUME splice variantsStructure-activity relationship of 2,2-dimethyl-2H-chromene based arylsulfonamide analogs of 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-phenylbenzenesulfonamide, a novel small molecule hypoxia inducible factor-1 (HIF-1) pathway inhibit[Retroviral reporter systems for the assessment of activity of stress-induced signal transduction pathways controlled by p53, HIF-1 and HSF-1 transcription factors].Hydrolysis of Glycosidic Flavonoids during the Preparation of Danggui Buxue Tang: An Outcome of Moderate Boiling of Chinese Herbal Mixture.Identification of a novel small molecule HIF-1alpha translation inhibitor.Stat3 activation is required for the growth of U87 cell-derived tumours in micePET radiopharmaceuticals for imaging of tumor hypoxia: a review of the evidenceSulfonamides as a new scaffold for hypoxia inducible factor pathway inhibitors.Assessment of hypoxia inducible factor levels in cancer cell lines upon hypoxic induction using a novel reporter constructConstitutively active Harvey Ras confers resistance to epidermal growth factor receptor-targeted therapy with cetuximab and gefitinib.Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1alpha signal pathways increases resistance to apoptosis by up-regulating survivin gene expression.Tumor-specific gene expression using the survivin promoter is further increased by hypoxiaDetailed assessment of gene activation levels by multiple hypoxia-responsive elements under various hypoxic conditions.AMPK-mediated energy homeostasis and associated metabolic effects on cancer cell response and resistance to cetuximab.Design and synthesis of novel small-molecule inhibitors of the hypoxia inducible factor pathwayMicrotubules regulate hypoxia-inducible factor-1α protein trafficking and activity: implications for taxane therapy.Reprogramming the Transcriptional Response to Hypoxia with a Chromosomally Encoded Cyclic Peptide HIF-1 Inhibitor.Targeted cancer gene therapy using a hypoxia inducible factor dependent oncolytic adenovirus armed with interleukin-4DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX.Regulation of gene expression by hypoxia: integration of the HIF-transduced hypoxic signal at the hypoxia-responsive elementEF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1.SEPT9_v1 up-regulates hypoxia-inducible factor 1 by preventing its RACK1-mediated degradation.Double oxygen-sensing vector system for robust hypoxia/ischemia-regulated gene induction in cardiac muscle in vitro and in vivo.Pan-PI-3 kinase inhibitor SF1126 shows antitumor and antiangiogenic activity in renal cell carcinoma.Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with cofactors p300/CBP.A novel hybrid promoter responsive to pathophysiological and pharmacological regulationAdenovirus-mediated hypoxia-targeted gene therapy using HSV thymidine kinase and bacterial nitroreductase prodrug-activating genes in vitro and in vivo.Development of an oncolytic herpes simplex virus using a tumor-specific HIF-responsive promoter.Rational design of minimal hypoxia-inducible enhancers.Three-dimensional cell organization leads to almost immediate HRE activity as demonstrated by molecular imaging of MG-63 spheroids using two-photon excitation microscopy.A novel adenoviral vector which mediates hypoxia-inducible gene expression selectively in neurons.Virus-based reporter systems for monitoring transcriptional activity of hypoxia-inducible factor 1.Utilizing tumor hypoxia to enhance oncolytic viral therapy in colorectal metastases.Optimizing combinations of flavonoids deriving from astragali radix in activating the regulatory element of erythropoietin by a feedback system control scheme.Adeno-associated viral vector-mediated hypoxia-regulated VEGF gene transfer promotes angiogenesis following focal cerebral ischemia in mice.Influences of HIF-lα on Bax/Bcl-2 and VEGF expressions in rats with spinal cord injuryHypoxia-inducible tumour-specific promoters as a dual-targeting transcriptional regulation system for cancer gene therapy.Second-generation HIF-activated oncolytic adenoviruses with improved replication, oncolytic, and antitumor efficacyAn insult-inducible vector system activated by hypoxia and oxidative stress for neuronal gene therapy.A Chinese herbal decoction, Jian-Pi-Yi-Shen, regulates the expressions of erythropoietin and pro-inflammatory cytokines in cultured cells.
P2860
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P2860
Generation of bidirectional hypoxia/HIF-responsive expression vectors to target gene expression to hypoxic cells.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Generation of bidirectional hy ...... e expression to hypoxic cells.
@en
Generation of bidirectional hy ...... e expression to hypoxic cells.
@nl
type
label
Generation of bidirectional hy ...... e expression to hypoxic cells.
@en
Generation of bidirectional hy ...... e expression to hypoxic cells.
@nl
prefLabel
Generation of bidirectional hy ...... e expression to hypoxic cells.
@en
Generation of bidirectional hy ...... e expression to hypoxic cells.
@nl
P2860
P356
P1433
P1476
Generation of bidirectional hy ...... e expression to hypoxic cells.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.GT.3301605
P577
2001-12-01T00:00:00Z
P5875
P6179
1009497532