Adenovirus-mediated gene transfer into human hepatocytes: analysis of the biochemical functionality of transduced cells.
about
A bovine papillomavirus-1 based vector restores the function of the low-density lipoprotein receptor in the receptor-deficient CHO-ldlA7 cell lineFoxa1 reduces lipid accumulation in human hepatocytes and is down-regulated in nonalcoholic fatty liver.Assessment of efficiency and safety of adenovirus mediated gene transfer into normal and damaged murine livers.Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies.Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs.Upgrading HepG2 cells with adenoviral vectors that encode drug-metabolizing enzymes: application for drug hepatotoxicity testing.HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved.Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells.Underexpressed coactivators PGC1alpha and SRC1 impair hepatocyte nuclear factor 4 alpha function and promote dedifferentiation in human hepatoma cells.Control of E1A under an E2F-1 promoter insulated with the myotonic dystrophy locus insulator reduces the toxicity of oncolytic adenovirus Ad-Delta24RGD.Coexpression of p21(WAF1/CIP1) in adenovirus vector transfected human primary hepatocytes prevents apoptosis resulting in improved transgene expression.CCAAT/enhancer-binding protein alpha (C/EBPalpha) and hepatocyte nuclear factor 4alpha (HNF4alpha) synergistically cooperate with constitutive androstane receptor to transactivate the human cytochrome P450 2B6 (CYP2B6) gene: application to the develSequential hepatogenic transdifferentiation of adipose tissue-derived stem cells: relevance of different extracellular signaling molecules, transcription factors involved, and expression of new key marker genes.Safe and efficient gene transfer into porcine hepatocytes using Sendai virus-cationic liposomes for bioartificial liver support.Rapid clearance of syngeneic transplanted hepatocytes following transduction with E-1-deleted adenovirus indicates early host immune responses and offers novel ways for studying viral vector, target cell and host interactions.Correction of ureagenesis after gene transfer in an animal model and after liver transplantation in humans with ornithine transcarbamylase deficiency.Interrogation of the Atherosclerosis-Associated SORT1 (Sortilin 1) Locus With Primary Human Hepatocytes, Induced Pluripotent Stem Cell-Hepatocytes, and Locus-Humanized Mice.
P2860
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P2860
Adenovirus-mediated gene transfer into human hepatocytes: analysis of the biochemical functionality of transduced cells.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Adenovirus-mediated gene trans ...... tionality of transduced cells.
@en
Adenovirus-mediated gene trans ...... tionality of transduced cells.
@nl
type
label
Adenovirus-mediated gene trans ...... tionality of transduced cells.
@en
Adenovirus-mediated gene trans ...... tionality of transduced cells.
@nl
prefLabel
Adenovirus-mediated gene trans ...... tionality of transduced cells.
@en
Adenovirus-mediated gene trans ...... tionality of transduced cells.
@nl
P2093
P356
P1433
P1476
Adenovirus-mediated gene trans ...... ctionality of transduced cells
@en
P2093
Gómez-Foix AM
Gómez-Lechón MJ
Hernández D
P2888
P304
P356
10.1038/SJ.GT.3300416
P577
1997-05-01T00:00:00Z
P5875
P6179
1012085842