Mode of action of C-1027, a new macromolecular antitumor antibiotic with highly potent cytotoxicity, on human hepatoma BEL-7402 cells.
about
Factor VII light chain-targeted lidamycin shows intensified therapeutic efficacy for liver cancer.Pharmacokinetics of C-1027 in mice as determined by TCA-RA method.Tissue distribution and excretion of 125I-lidamycin in mice and rats.Antitumor efficacy of lidamycin on hepatoma and active moiety of its moleculeDNA damage by C1027 involves hydrogen atom abstraction and addition to nucleobases.Antitumor effects of an engineered and energized fusion protein consisting of an anti-CD20 scFv fragment and lidamycin.Inhibition of mouse embryonic carcinoma cell growth by lidamycin through down-regulation of embryonic stem cell-like genes Oct4, Sox2 and Myc.Efficient inhibition of B-cell lymphoma xenografts with a novel recombinant fusion protein: anti-CD20Fab-LDM.Cellular responses to the DNA strand-scission enediyne C-1027 can be independent of ATM, ATR, and DNA-PK kinases.
P2860
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P2860
Mode of action of C-1027, a new macromolecular antitumor antibiotic with highly potent cytotoxicity, on human hepatoma BEL-7402 cells.
description
1990 nî lūn-bûn
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1990年の論文
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1990年学术文章
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1990年学术文章
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1990年學術文章
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name
Mode of action of C-1027, a ne ...... human hepatoma BEL-7402 cells.
@en
Mode of action of C-1027, a ne ...... human hepatoma BEL-7402 cells.
@nl
type
label
Mode of action of C-1027, a ne ...... human hepatoma BEL-7402 cells.
@en
Mode of action of C-1027, a ne ...... human hepatoma BEL-7402 cells.
@nl
prefLabel
Mode of action of C-1027, a ne ...... human hepatoma BEL-7402 cells.
@en
Mode of action of C-1027, a ne ...... human hepatoma BEL-7402 cells.
@nl
P2093
P356
P1476
Mode of action of C-1027, a ne ...... human hepatoma BEL-7402 cells.
@en
P2093
P2888
P356
10.1007/BF00689274
P577
1990-01-01T00:00:00Z
P6179
1028003066