Determination of microsome and hepatocyte scaling factors for in vitro/in vivo extrapolation in the rat and dog.
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Microsomal and Cytosolic Scaling Factors in Dog and Human Kidney Cortex and Application for In Vitro-In Vivo Extrapolation of Renal Metabolic ClearanceOptimization of intestinal microsomal preparation in the rat: A systematic approach to assess the influence of various methodologies on metabolic activity and scaling factors.Cloning/characterization of the canine organic anion transporting polypeptide 1b4 (Oatp1b4) and classification of the canine OATP/SLCO membersSandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity.Benzimidazole analogs as potent hypoxia inducible factor inhibitors: synthesis, biological evaluation, and profiling drug-like propertiesProbe ADME and test hypotheses: a PATH beyond clearance in vitro-in vivo correlations in early drug discovery.Stereological assessment of sexual dimorphism in the rat liver reveals differences in hepatocytes and Kupffer cells but not hepatic stellate cells.Transport-Metabolism Interplay of Atazanavir in Rat Hepatocytes.Optimizing the use of rainbow trout hepatocytes for bioaccumulation assessments with fish.Verapamil hepatic clearance in four preclinical rat models: towards activity-based scaling.Quantifying gut wall metabolism: methodology matters.Mass spectrometry-based quantification of CYP enzymes to establish in vitro/in vivo scaling factors for intestinal and hepatic metabolism in beagle dog.The Effects of Aging on Hepatic Microsomal Scaling Factor and Hepatocellularity Number in the Horse.Quantitative ADME proteomics - CYP and UGT enzymes in the Beagle dog liver and intestine.Practical use of the regression offset approach for the prediction of in vivo intrinsic clearance from hepatocytes.
P2860
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P2860
Determination of microsome and hepatocyte scaling factors for in vitro/in vivo extrapolation in the rat and dog.
description
2008 nî lūn-bûn
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2008年の論文
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2008年学术文章
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2008年学术文章
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2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
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2008年学术文章
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2008年學術文章
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2008年學術文章
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name
Determination of microsome and ...... rapolation in the rat and dog.
@en
Determination of microsome and ...... rapolation in the rat and dog.
@nl
type
label
Determination of microsome and ...... rapolation in the rat and dog.
@en
Determination of microsome and ...... rapolation in the rat and dog.
@nl
prefLabel
Determination of microsome and ...... rapolation in the rat and dog.
@en
Determination of microsome and ...... rapolation in the rat and dog.
@nl
P2093
P2860
P1433
P1476
Determination of microsome and ...... rapolation in the rat and dog.
@en
P2093
H H Griffiths
P G Ballard
R D O Jones
P2860
P304
P356
10.1080/00498250802491662
P407
P577
2008-11-01T00:00:00Z