Brca1 heterozygous mice have shortened life span and are prone to ovarian tumorigenesis with haploinsufficiency upon ionizing irradiation.
about
RINT-1 serves as a tumor suppressor and maintains Golgi dynamics and centrosome integrity for cell survivalGenetics and epigenetics of aging and longevityLoss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic diseaseCRL4Cdt2: master coordinator of cell cycle progression and genome stabilityMolecular profiles of hereditary epithelial ovarian cancers and their implications for the biology of this disease.Transcriptional regulation of the base excision repair pathway by BRCA1Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans.The role of BRCA1 in DNA damage response.Mechanisms of increased risk of tumorigenesis in Atm and Brca1 double heterozygosity.Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells.BRE plays an essential role in preventing replicative and DNA damage-induced premature senescence.Evolutionary dynamics of BRCA1 alterations in breast tumorigenesis.Germline BRCA1 mutation reprograms breast epithelial cell metabolism towards mitochondrial-dependent biosynthesis: evidence for metformin-based "starvation" strategies in BRCA1 carriers.Haploinsufficiency in mouse models of DNA repair deficiency: modifiers of penetrance.Hereditary breast and ovarian cancer: new genes in confined pathways.BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers.A Reassessment of Genes Modulating Aging in Mice Using Demographic Measurements of the Rate of Aging.SYK expression level distinguishes control from BRCA1-mutated lymphocytes.
P2860
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P2860
Brca1 heterozygous mice have shortened life span and are prone to ovarian tumorigenesis with haploinsufficiency upon ionizing irradiation.
description
2007 nî lūn-bûn
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2007年の論文
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2007年学术文章
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2007年学术文章
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2007年学术文章
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2007年学术文章
@zh-hans
2007年学术文章
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2007年学术文章
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2007年學術文章
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2007年學術文章
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name
Brca1 heterozygous mice have s ...... ncy upon ionizing irradiation.
@en
Brca1 heterozygous mice have s ...... ncy upon ionizing irradiation.
@nl
type
label
Brca1 heterozygous mice have s ...... ncy upon ionizing irradiation.
@en
Brca1 heterozygous mice have s ...... ncy upon ionizing irradiation.
@nl
prefLabel
Brca1 heterozygous mice have s ...... ncy upon ionizing irradiation.
@en
Brca1 heterozygous mice have s ...... ncy upon ionizing irradiation.
@nl
P2093
P2860
P356
P1433
P1476
Brca1 heterozygous mice have s ...... ncy upon ionizing irradiation.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1210451
P407
P50
P577
2007-04-09T00:00:00Z
P5875
P6179
1048892895