Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS).
about
Environment-transformable sequence-structure relationship: a general mechanism for proteotoxicity.Pathological hydrogen peroxide triggers the fibrillization of wild-type SOD1 via sulfenic acid modification of Cys-111.Lysine acylation in superoxide dismutase-1 electrostatically inhibits formation of fibrils with prion-like seeding.Atomic structures of corkscrew-forming segments of SOD1 reveal varied oligomer conformations.Elucidating the Structures of Amyloid Oligomers with Macrocyclic β-Hairpin Peptides: Insights into Alzheimer's Disease and Other Amyloid Diseases.Tryptophan 32-mediated SOD1 aggregation is attenuated by pyrimidine-like compounds in living cellsLarge SOD1 aggregates, unlike trimeric SOD1, do not impact cell viability in a model of amyotrophic lateral sclerosisCu selective chelators relieve copper-induced oxidative stress
P2860
Q47330876-00537625-0F83-473A-9C10-31B41AB1546FQ47550175-8A2A8628-8BBB-4BDA-B013-4169046DF687Q47703808-54FB78C1-10A4-4CDD-BC1A-0C9BB8C52D4CQ49907306-22937BE8-F92E-4006-AC14-919CA66CC792Q52672253-2653086A-7A34-4DB4-8518-2C17EADAE6E5Q57805726-B8D8C848-E4F0-4E05-A60B-B6D2EA29D0F0Q57829032-764F4A87-749B-4F4B-821E-81612E74CC8FQ59137566-9983A500-E9A6-4DAF-9C6C-BFCBC55908FD
P2860
Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS).
description
2017 nî lūn-bûn
@nan
2017年の論文
@ja
2017年学术文章
@wuu
2017年学术文章
@zh
2017年学术文章
@zh-cn
2017年学术文章
@zh-hans
2017年学术文章
@zh-my
2017年学术文章
@zh-sg
2017年學術文章
@yue
2017年學術文章
@zh-hant
name
Atomic structure of a toxic, o ...... ophic lateral sclerosis (ALS).
@en
Atomic structure of a toxic, o ...... ophic lateral sclerosis (ALS).
@nl
type
label
Atomic structure of a toxic, o ...... ophic lateral sclerosis (ALS).
@en
Atomic structure of a toxic, o ...... ophic lateral sclerosis (ALS).
@nl
prefLabel
Atomic structure of a toxic, o ...... ophic lateral sclerosis (ALS).
@en
Atomic structure of a toxic, o ...... ophic lateral sclerosis (ALS).
@nl
P2093
P2860
P50
P356
P1476
Atomic structure of a toxic, o ...... rophic lateral sclerosis (ALS)
@en
P2093
Albert C Pan
Angela B Soriaga
Bennett G Novitch
Christina K Jayson
David E Shaw
David S Eisenberg
Destaye M Moore
Elizabeth L Guenther
Lukasz Goldschmidt
P2860
P304
P356
10.1073/PNAS.1705091114
P407
P577
2017-07-31T00:00:00Z