Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice.
about
Dopamine release in the basal gangliaInactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunctionGenetically engineered mouse models of Parkinson's diseasePreservation of function in Parkinson's disease: what's learning got to do with it?PINK1-mediated phosphorylation of Parkin boosts Parkin activity in DrosophilaParkinson's disease: animal models and dopaminergic cell vulnerabilitySTEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson's diseaseDeficient Wnt signalling triggers striatal synaptic degeneration and impaired motor behaviour in adult miceModelling idiopathic Parkinson disease as a complex illness can inform incidence rate in healthy adults: the PREDIGT scoreRGS4 is required for dopaminergic control of striatal LTD and susceptibility to parkinsonian motor deficitsMitochondrial quality control mediated by PINK1 and Parkin: links to parkinsonism.Diversity in the regulation of autophagy and mitophagy: lessons from Parkinson's disease.Altered hippocampal synaptic physiology in aged parkin-deficient mice.Ubiquitination increases parkin activity to promote autophagic α-synuclein clearance.Unaltered striatal dopamine release levels in young Parkin knockout, Pink1 knockout, DJ-1 knockout and LRRK2 R1441G transgenic mice.Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson's disease.Mice lacking the PSD-95-interacting E3 ligase, Dorfin/Rnf19a, display reduced adult neurogenesis, enhanced long-term potentiation, and impaired contextual fear conditioningNeuronopathic Gaucher disease: dysregulated mRNAs and miRNAs in brain pathogenesis and effects of pharmacologic chaperone treatment in a mouse modelExpression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment.Methyl-Arginine Profile of Brain from Aged PINK1-KO+A53T-SNCA Mice Suggests Altered Mitochondrial Biogenesis.AF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinson's disease.Oxidative stress mechanisms underlying Parkinson's disease-associated neurodegeneration in C. elegans.Parkin Deficiency Reduces Hippocampal Glutamatergic Neurotransmission by Impairing AMPA Receptor Endocytosis.Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson's disease.Synaptic dysfunction in genetic models of Parkinson's disease: a role for autophagy?Neuromodulatory control of striatal plasticity and behavior.Presenilins in synaptic function and disease.Oxidative stress in genetic mouse models of Parkinson's disease.Presynaptic dysfunction in Parkinson's disease: a focus on LRRK2.The vesicular monoamine transporter 2: an underexplored pharmacological target.Synaptic signalling and its interface with neuropathologies: snapshots from the past, present and future.PINK1 heterozygous mutations induce subtle alterations in dopamine-dependent synaptic plasticity.Impaired neurotransmitter release in Alzheimer's and Parkinson's diseases.Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice.Synapses in neurodegenerative diseases.parkin-induced defects in neurophysiology and locomotion are generated by metabolic dysfunction and not oxidative stress.LRRK2 R1441G mice are more liable to dopamine depletion and locomotor inactivity.Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson's disease-like pathology.Autophagy impairment in Parkinson's disease.
P2860
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P2860
Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice.
@en
Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice.
@nl
type
label
Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice.
@en
Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice.
@nl
prefLabel
Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice.
@en
Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice.
@nl
P2093
P50
P1476
Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice
@en
P2093
Antonio Pisani
Maha Karouani
Paola Platania
Tohru Kitada
P304
P356
10.1111/J.1471-4159.2009.06152.X
P407
P577
2009-05-05T00:00:00Z