A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways.
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A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americansThe pharmacogenetic control of antiplatelet response: candidate genes and CYP2C19Neutrophil AKT2 regulates heterotypic cell-cell interactions during vascular inflammationComparison of methods for competitive tests of pathway analysisOff-target platelet activation in macaques unique to a therapeutic monoclonal antibody.PEAR1 is not a major susceptibility gene for cardiovascular disease in a Flemish population.SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume.Platelet function is modified by common sequence variation in megakaryocyte super enhancersLarge multiethnic Candidate Gene Study for C-reactive protein levels: identification of a novel association at CD36 in African AmericansMaps of open chromatin guide the functional follow-up of genome-wide association signals: application to hematological traits.The genetics of normal platelet reactivity.Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function.Rare platelet GPCR variants: what can we learn?Historical lessons in translational medicine: cyclooxygenase inhibition and P2Y12 antagonism.Genetic sequence analysis of inherited bleeding diseases.Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.Evaluation of Novel Platelet Polymorphisms in Stroke. Dichotomic Effect of rs5443 in GNB3.The genetics of common variation affecting platelet development, function and pharmaceutical targeting.Novel loci involved in platelet function and platelet count identified by a genome-wide study performed in children.Identification of a specific intronic PEAR1 gene variant associated with greater platelet aggregability and protein expression.Genetic Variation in the Platelet Endothelial Aggregation Receptor 1 Gene Results in Endothelial Dysfunction.GWAS and transcriptional analysis prioritize ITPR1 and CNTN4 for a serum uric acid 3p26 QTL in Mexican AmericansZebrafish thrombocytes: functions and originsMicrofluidic assessment of functional culture-derived platelets in human thrombi under flow.Reactome - a curated knowledgebase of biological pathways: megakaryocytes and platelets.A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and functionJAK2V617F leads to intrinsic changes in platelet formation and reactivity in a knock-in mouse model of essential thrombocythemia.Identification of ITGA2B and ITGB3 Single-Nucleotide Polymorphisms and Their Influences on the Platelet FunctionPECAM-1 expression and activity negatively regulate multiple platelet signaling pathways.Platelet responses to agonists in a cohort of highly characterised platelet donors are consistent over timeAkt signaling in platelets and thrombosis.Pharmacokinetic and Pharmacodynamic Responses to Clopidogrel: Evidences and Perspectives.Platelet physiology and antiplatelet agents.Systems biology of platelet-vessel wall interactions.The effect of purity upon the triple-helical stability of collagenous peptides.Platelet genomics: the role of platelet size and number in health and disease.RAPIDSNPs: A new computational pipeline for rapidly identifying key genetic variants reveals previously unidentified SNPs that are significantly associated with individual platelet responsesCommon genetic variants in platelet surface receptors and its association with ischemic stroke.Replication and hematological characterization of human platelet reactivity genetic associations in men from the Caerphilly Prospective Study (CaPS).Two novel pathway analysis methods based on a hierarchical model.
P2860
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P2860
A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
A functional genomics approach ...... h platelet signaling pathways.
@en
A functional genomics approach ...... h platelet signaling pathways.
@nl
type
label
A functional genomics approach ...... h platelet signaling pathways.
@en
A functional genomics approach ...... h platelet signaling pathways.
@nl
prefLabel
A functional genomics approach ...... h platelet signaling pathways.
@en
A functional genomics approach ...... h platelet signaling pathways.
@nl
P2093
P50
P1433
P1476
A functional genomics approach ...... h platelet signaling pathways.
@en
P2093
Adam Walker
Alison Coffey
Angela Rankin
Bernard de Bono
Bloodomics Consortium
Catherine M Rice
David Bentley
Jan-Willem Akkerman
Jane Rogers
Jonathan Stephens
P304
P356
10.1182/BLOOD-2009-02-202614
P407
P577
2009-05-08T00:00:00Z