Structure-based virtual screening for plant-based ERbeta-selective ligands as potential preventative therapy against age-related neurodegenerative diseases.
about
Discovery and resupply of pharmacologically active plant-derived natural products: A reviewAdaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous systemUnderstanding nuclear receptors using computational methods.Analysis of structure-based virtual screening studies and characterization of identified active compounds.Early intervention with an estrogen receptor β-selective phytoestrogenic formulation prolongs survival, improves spatial recognition memory, and slows progression of amyloid pathology in a female mouse model of Alzheimer's disease.Virtual screening of the estrogen receptor.Membrane estrogen receptors mediate calcium signaling and MAP kinase activation in individual hippocampal neurons.The effect of dietary soy isoflavones before and after ovariectomy on hippocampal protein markers of mitochondrial bioenergetics and antioxidant activity in female monkeysIn silico pharmacology for drug discovery: applications to targets and beyondEstrogen receptor β in Alzheimer's disease: From mechanisms to therapeutics.Metal complex SERMs (selective oestrogen receptor modulators). The influence of different metal units on breast cancer cell antiproliferative effects.Ligand discovery and virtual screening using the program LIDAEUS.Does phytoestrogen supplementation affect cognition differentially in males and females?Dehydrogenation of the indoline-containing drug 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (indapamide) by CYP3A4: correlation with in silico predictionsSteroid-binding G-protein-coupled receptors: new drug discovery targets for old ligands.A systematic approach to prioritize drug targets using machine learning, a molecular descriptor-based classification model, and high-throughput screening of plant derived molecules: a case study in oral cancer.Structure-based quantitative structure--activity relationship modeling of estrogen receptor β-ligands.Pharmacokinetics and safety profile of single-dose administration of an estrogen receptor β-selective phytoestrogenic (phytoSERM) formulation in perimenopausal and postmenopausal women.Estrogen receptor beta, but not alpha, mediates estrogen's effect on cocaine-induced reinstatement of extinguished cocaine-seeking behavior in ovariectomized female rats.Total syntheses of gerberinol I and the pterophyllins 2 and 4 using the Casnati-Skattebøl reaction under different conditions.Copper(II) bromide-catalyzed intramolecular decarboxylative functionalization to form a C(sp(3))-O bond for the synthesis of furo[3,2-c]coumarins.An efficient one-pot approach for the regio- and diastereoselective synthesis of trans-dihydrofuran derivatives: cytotoxicity and DNA-binding studies.LASSO-ing Potential Nuclear Receptor Agonists and Antagonists: A New Computational Method for Database Screening
P2860
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P2860
Structure-based virtual screening for plant-based ERbeta-selective ligands as potential preventative therapy against age-related neurodegenerative diseases.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Structure-based virtual screen ...... ed neurodegenerative diseases.
@en
Structure-based virtual screen ...... ed neurodegenerative diseases.
@nl
type
label
Structure-based virtual screen ...... ed neurodegenerative diseases.
@en
Structure-based virtual screen ...... ed neurodegenerative diseases.
@nl
prefLabel
Structure-based virtual screen ...... ed neurodegenerative diseases.
@en
Structure-based virtual screen ...... ed neurodegenerative diseases.
@nl
P356
P1476
Structure-based virtual screen ...... ed neurodegenerative diseases.
@en
P2093
Liqin Zhao
Roberta D Brinton
P304
P356
10.1021/JM0490538
P407
P577
2005-05-01T00:00:00Z