Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide.
about
Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases?Implications of the serine protease HtrA1 in amyloid precursor protein processingSynaptic plasticity in animal models of early Alzheimer's diseaseModulation of statin-activated shedding of Alzheimer APP ectodomain by ROCKCholesterol balance in prion diseases and Alzheimer's diseaseAlzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzymeProcessing of the pre-beta-amyloid protein by cathepsin D is enhanced by a familial Alzheimer's disease mutationIncreased secreted amyloid precursor protein-α (sAPPα) in severe autism: proposal of a specific, anabolic pathway and putative biomarkerMunc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processingSerotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretionThe normal and pathologic roles of the Alzheimer's β-secretase, BACE1Neuronal and glial beta-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology.Molecular mechanisms for Alzheimer's disease: implications for neuroimaging and therapeutics.A splice variant of beta-secretase deficient in the amyloidogenic processing of the amyloid precursor protein.Differential recognition of vascular and parenchymal beta amyloid deposition.The amyloid precursor protein of Alzheimer's disease and the Abeta peptide.Cellular mechanisms of beta-amyloid production and secretioncDNA cloning and molecular characterization of human brain metalloprotease MP100: a beta-secretase candidate?The beta-amyloid precursor protein and its derivatives: from biology to learning and memory processes.The secretases: enzymes with therapeutic potential in Alzheimer disease.Beta-secretase: structure, function, and evolution.Activation of TRPML1 clears intraneuronal Aβ in preclinical models of HIV infection.BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's diseaseThe functions of the amyloid precursor protein gene.Secretases as therapeutic targets for the treatment of Alzheimer's disease.Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease.Development of a novel β-secretase binding assay using the AlphaScreen platform.Potential novel targets for Alzheimer pharmacotherapy: I. Secretases.Alpha 1-antichymotrypsin regulates Alzheimer beta-amyloid peptide fibril formation.The amyloid beta ion channel hypothesis of Alzheimer's disease.Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of beta-amyloid-mediated cell deathAn Alzheimer's disease hypothesis based on transcriptional dysregulation.Independent relationship between amyloid precursor protein (APP) dimerization and γ-secretase processivity.The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer's disease brain.Predominant deposition of amyloid-beta 42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene.Effects of membrane lipids on the activity and processivity of purified γ-secretaseAmyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease.Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formationPresenilin function and gamma-secretase activity.The amyloid precursor protein copper binding domain histidine residues 149 and 151 mediate APP stability and metabolism.
P2860
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P2860
Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh-hant
name
Secretion of beta-amyloid prec ...... s of the beta-amyloid peptide.
@en
Secretion of beta-amyloid prec ...... s of the beta-amyloid peptide.
@nl
type
label
Secretion of beta-amyloid prec ...... s of the beta-amyloid peptide.
@en
Secretion of beta-amyloid prec ...... s of the beta-amyloid peptide.
@nl
prefLabel
Secretion of beta-amyloid prec ...... s of the beta-amyloid peptide.
@en
Secretion of beta-amyloid prec ...... s of the beta-amyloid peptide.
@nl
P2093
P356
P1433
P1476
Secretion of beta-amyloid prec ...... s of the beta-amyloid peptide.
@en
P2093
Blomquist C
Oltersdorf T
P2888
P304
P356
10.1038/361260A0
P407
P577
1993-01-01T00:00:00Z
P6179
1030813306