The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations.
about
Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light.Lessons from a tarantula: new insights into myosin interacting-heads motif evolution and its implications on disease.Omecamtiv mercabil and blebbistatin modulate cardiac contractility by perturbing the regulatory state of the myosin filament.A mixed-kinetic model describes unloaded velocities of smooth, skeletal, and cardiac muscle myosin filaments in vitro.Hypertrophic cardiomyopathy mutation R58Q in the myosin regulatory light chain perturbs thick filament-based regulation in cardiac muscle.Interacting-heads motif has been conserved as a mechanism of myosin II inhibition since before the origin of animals.Dilated cardiomyopathy myosin mutants have reduced force-generating capacity.Burst-Like Transcription of Mutant and Wildtype MYH7-Alleles as Possible Origin of Cell-to-Cell Contractile Imbalance in Hypertrophic Cardiomyopathy.Do Actomyosin Single-Molecule Mechanics Data Predict Mechanics of Contracting Muscle?Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibitionControlling load-dependent kinetics of β-cardiac myosin at the single-molecule levelImpact of the Myosin Modulator Mavacamten on Force Generation and Cross-Bridge Behavior in a Murine Model of HypercontractilityProlonged cross-bridge binding triggers muscle dysfunction in a model of myosin-based hypertrophic cardiomyopathy
P2860
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P2860
The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations.
description
2017 nî lūn-bûn
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2017年の論文
@ja
2017年学术文章
@wuu
2017年学术文章
@zh
2017年学术文章
@zh-cn
2017年学术文章
@zh-hans
2017年学术文章
@zh-my
2017年学术文章
@zh-sg
2017年學術文章
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2017年學術文章
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name
The myosin mesa and the basis ...... phic cardiomyopathy mutations.
@en
The myosin mesa and the basis ...... phic cardiomyopathy mutations.
@nl
type
label
The myosin mesa and the basis ...... phic cardiomyopathy mutations.
@en
The myosin mesa and the basis ...... phic cardiomyopathy mutations.
@nl
prefLabel
The myosin mesa and the basis ...... phic cardiomyopathy mutations.
@en
The myosin mesa and the basis ...... phic cardiomyopathy mutations.
@nl
P2093
P2860
P356
P1476
The myosin mesa and the basis ...... phic cardiomyopathy mutations.
@en
P2093
Arjun S Adhikari
Darshan V Trivedi
James A Spudich
Kathleen M Ruppel
Margaret S Sunitha
Saswata S Sarkar
Shirley Sutton
P2860
P2888
P304
P356
10.1038/NSMB.3408
P577
2017-05-08T00:00:00Z
P6179
1085211549