Role for cyclin A-dependent kinase in DNA replication in human S phase cell extracts.
about
Identification of DNA replication and cell cycle proteins that interact with PCNARetinoblastoma tumor suppressor protein signals through inhibition of cyclin-dependent kinase 2 activity to disrupt PCNA function in S phase.Identification of an hexapeptide that binds to a surface pocket in cyclin A and inhibits the catalytic activity of the complex cyclin-dependent kinase 2-cyclin A.In vivo accumulation of cyclin A and cellular replication factors in autonomous parvovirus minute virus of mice-associated replication bodies.Transactivation of murine cyclin A by polyomavirus large and small T antigens.SP600125 suppresses Cdk1 and induces endoreplication directly from G2 phase, independent of JNK inhibition.Substrate degradation by the anaphase promoting complex occurs during mitotic slippage.Elevated cyclin A associated kinase activity promotes sensitivity of metastatic human cancer cells to DNA antimetabolite drugPhosphorylation of the PCNA binding domain of the large subunit of replication factor C on Thr506 by cyclin-dependent kinases regulates binding to PCNACyclin A activates the DNA polymerase delta -dependent elongation machinery in vitro: A parvovirus DNA replication modelDNA damage triggers p21WAF1-dependent Emi1 down-regulation that maintains G2 arrest.Proliferating cell nuclear antigen recruits cyclin-dependent kinase inhibitor Xic1 to DNA and couples its proteolysis to DNA polymerase switching.Differential prognostic impact of the cyclins E and B in premenopausal and postmenopausal women with lymph node-negative breast cancer.Overexpression of non‑SMC condensin I complex subunit G serves as a promising prognostic marker and therapeutic target for hepatocellular carcinoma.Human topoisomerase I promotes initiation of simian virus 40 DNA replication in vitro.Binding of polyomavirus small T antigen to protein phosphatase 2A is required for elimination of p27 and support of S-phase induction in concert with large T antigen.Cdk2 associates with MAP kinase in vivo and its nuclear translocation is dependent on MAP kinase activation in IL-2-dependent Kit 225 T lymphocytes.A direct interaction between proliferating cell nuclear antigen (PCNA) and Cdk2 targets PCNA-interacting proteins for phosphorylation.In vitro chromatin remodelling by chromatin accessibility complex (CHRAC) at the SV40 origin of DNA replication.Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway.Human cyclin A is required for mitosis until mid prophase.Histone octamer dissociation is not required for in vitro replication of simian virus 40 minichromosomes.Involvement of topoisomerases in the initiation of simian virus 40 minichromosome replication.C-terminal deletion mutant p21(WAF1/CIP1) enhances E2F-1-mediated apoptosis in colon adenocarcinoma cells.Cyclin A-dependent kinase activity affects chromatin binding of ORC, Cdc6, and MCM in egg extracts of Xenopus laevis.RNAi‑mediated downregulation of asparaginase‑like protein 1 inhibits growth and promotes apoptosis of human cervical cancer line SiHa.
P2860
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P2860
Role for cyclin A-dependent kinase in DNA replication in human S phase cell extracts.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Role for cyclin A-dependent kinase in DNA replication in human S phase cell extracts.
@en
Role for cyclin A-dependent kinase in DNA replication in human S phase cell extracts.
@nl
type
label
Role for cyclin A-dependent kinase in DNA replication in human S phase cell extracts.
@en
Role for cyclin A-dependent kinase in DNA replication in human S phase cell extracts.
@nl
prefLabel
Role for cyclin A-dependent kinase in DNA replication in human S phase cell extracts.
@en
Role for cyclin A-dependent kinase in DNA replication in human S phase cell extracts.
@nl
P2093
P2860
P356
P1476
Role for cyclin A-dependent kinase in DNA replication in human S phase cell extracts.
@en
P2093
Cannella D
Fitzgerald P
Rousselle T
P2860
P304
31627-31637
P356
10.1074/JBC.271.49.31627
P407
P577
1996-12-01T00:00:00Z