Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex.
about
Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaksCoordination of DNA damage responses via the Smc5/Smc6 complexIdentification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complexComposition and architecture of the Schizosaccharomyces pombe Rad18 (Smc5-6) complexHuman MMS21/NSE2 is a SUMO ligase required for DNA repairProteins with two SUMO-like domains in chromatin-associated complexes: the RENi (Rad60-Esc2-NIP45) familyFunctions of Ubiquitin and SUMO in DNA Replication and Replication StressCooperativity of the SUMO and Ubiquitin Pathways in Genome StabilitySMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions.A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organizationRequirement of Nse1, a subunit of the Smc5-Smc6 complex, for Rad52-dependent postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae.Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex.Structural maintenance of chromosomes (SMC) proteins promote homolog-independent recombination repair in meiosis crucial for germ cell genomic stability.Non-SMC elements 1 and 3 are required for early embryo and seedling development in Arabidopsis.Sumoylation: a new wrestler in the DNA repair ringHypomorphism in human NSMCE2 linked to primordial dwarfism and insulin resistance.Evolutionarily conserved genetic interactions with budding and fission yeast MutS identify orthologous relationships in mismatch repair-deficient cancer cells.Smc5p promotes faithful chromosome transmission and DNA repair in Saccharomyces cerevisiae.Brc1-mediated DNA repair and damage toleranceSmc5/6-Mms21 prevents and eliminates inappropriate recombination intermediates in meiosis.Roles of vertebrate Smc5 in sister chromatid cohesion and homologous recombinational repair.Evolution of the Max and Mlx networks in animals.The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complexATPase-dependent control of the Mms21 SUMO ligase during DNA repair.Nse1-dependent recruitment of Smc5/6 to lesion-containing loci contributes to the repair defects of mutant complexesMms22 preserves genomic integrity during DNA replication in Schizosaccharomyces pombe.NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activitySMC complexes in bacterial chromosome condensation and segregation.Meiotic DNA joint molecule resolution depends on Nse5-Nse6 of the Smc5-Smc6 holocomplexGenomic analyses reveal FAM84B and the NOTCH pathway are associated with the progression of esophageal squamous cell carcinoma.Chromatin association of the SMC5/6 complex is dependent on binding of its NSE3 subunit to DNA.Nse1 RING-like domain supports functions of the Smc5-Smc6 holocomplex in genome stability.The Saccharomyces cerevisiae Esc2 and Smc5-6 proteins promote sister chromatid junction-mediated intra-S repair.Proteomics Analysis with a Nano Random Forest Approach Reveals Novel Functional Interactions Regulated by SMC Complexes on Mitotic Chromosomes.Association of chromosome 8q variants with prostate cancer risk in Caucasian and Hispanic menGenome stability roles of SUMO-targeted ubiquitin ligases.Incision of damaged DNA in the presence of an impaired Smc5/6 complex imperils genome stabilitySmc5/6-mediated regulation of replication progression contributes to chromosome assembly during mitosis in human cells.Rad62 protein functionally and physically associates with the smc5/smc6 protein complex and is required for chromosome integrity and recombination repair in fission yeast.Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis.
P2860
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P2860
Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex.
description
2003 nî lūn-bûn
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2003年の論文
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2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年学术文章
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name
Novel essential DNA repair pro ...... ssion yeast Smc5-Smc6 complex.
@en
Novel essential DNA repair pro ...... ssion yeast Smc5-Smc6 complex.
@nl
type
label
Novel essential DNA repair pro ...... ssion yeast Smc5-Smc6 complex.
@en
Novel essential DNA repair pro ...... ssion yeast Smc5-Smc6 complex.
@nl
prefLabel
Novel essential DNA repair pro ...... ssion yeast Smc5-Smc6 complex.
@en
Novel essential DNA repair pro ...... ssion yeast Smc5-Smc6 complex.
@nl
P2093
P2860
P356
P1476
Novel essential DNA repair pro ...... ission yeast Smc5-Smc6 complex
@en
P2093
John R Yates
Michael N Boddy
Yelena Pavlova
P2860
P304
45460-45467
P356
10.1074/JBC.M308828200
P407
P577
2003-09-08T00:00:00Z