DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis.
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Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cellsA predominant role of acyl-CoA:monoacylglycerol acyltransferase-2 in dietary fat absorption implicated by tissue distribution, subcellular localization, and up-regulation by high fat dietCD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the bloodAcylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorptionThe role of enterocyte defects in the pathogenesis of congenital diarrheal disordersIntestinal triacylglycerol synthesis in fat absorption and systemic energy metabolismIntestine-targeted DGAT1 inhibition improves obesity and insulin resistance without skin aberrations in miceDiacylglycerol acyltransferase-1 inhibition enhances intestinal fatty acid oxidation and reduces energy intake in ratsDGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytesCloning and functional characterization of a mouse intestinal acyl-CoA:monoacylglycerol acyltransferase, MGAT2CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestineThe biogenesis of chylomicronsUsing fluorescent lipids in live zebrafish larvae: From imaging whole animal physiology to subcellular lipid trafficking.Zebrafish lipid metabolism: from mediating early patterning to the metabolism of dietary fat and cholesterol.Lactobacillus rhamnosus lowers zebrafish lipid content by changing gut microbiota and host transcription of genes involved in lipid metabolism.Disruption of retinoblastoma protein expression in the intestinal epithelium impairs lipid absorptionIntestinally Targeted Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitors Robustly Suppress Postprandial Triglycerides.Intestine-specific deletion of acyl-CoA:monoacylglycerol acyltransferase (MGAT) 2 protects mice from diet-induced obesity and glucose intolerance.Lipid oversupply, selective insulin resistance, and lipotoxicity: molecular mechanismsIntestine-specific expression of acyl CoA:diacylglycerol acyltransferase 1 reverses resistance to diet-induced hepatic steatosis and obesity in Dgat1-/- miceIdentification of acyl coenzyme A:monoacylglycerol acyltransferase 3, an intestinal specific enzyme implicated in dietary fat absorption.Deletion of Tis7 protects mice from high-fat diet-induced weight gain and blunts the intestinal adaptive response postresection.Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells.Diacylglycerol acyltransferase-1 (DGAT1) inhibition perturbs postprandial gut hormone release.Novel acyl-coenzyme A:monoacylglycerol acyltransferase plays an important role in hepatic triacylglycerol secretion.Determination of PF-04620110, a novel inhibitor of diacylglycerol acyltransferase-1, in rat plasma using liquid chromatography-tandem mass spectrometry and its application in pharmacokinetic studies.Sequential regulation of diacylglycerol acyltransferase 2 expression by CAAT/enhancer-binding protein beta (C/EBPbeta) and C/EBPalpha during adipogenesis.Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis.Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids.Intestinal acyl-CoA:diacylglycerol acyltransferase 2 overexpression enhances postprandial triglyceridemic response and exacerbates high fat diet-induced hepatic triacylglycerol storageEffect of the DGAT1 inhibitor pradigastat on triglyceride and apoB48 levels in patients with familial chylomicronemia syndromePhenotypic population screen identifies a new mutation in bovine DGAT1 responsible for unsaturated milk fatRole of the gut in modulating lipoprotein metabolism.Mammalian triacylglycerol metabolism: synthesis, lipolysis, and signalingLack of acyl-CoA:diacylglycerol acyltransferase 1 reduces intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein E knockout mice.Mobilisation of enterocyte fat stores by oral glucose in humans.Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity.Glycerol-3-phosphate Acyltransferase Isoform-4 (GPAT4) Limits Oxidation of Exogenous Fatty Acids in Brown AdipocytesDeficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice.Gut triglyceride production.
P2860
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P2860
DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
DGAT1 is not essential for int ...... tion or chylomicron synthesis.
@en
DGAT1 is not essential for int ...... tion or chylomicron synthesis.
@nl
type
label
DGAT1 is not essential for int ...... tion or chylomicron synthesis.
@en
DGAT1 is not essential for int ...... tion or chylomicron synthesis.
@nl
prefLabel
DGAT1 is not essential for int ...... tion or chylomicron synthesis.
@en
DGAT1 is not essential for int ...... tion or chylomicron synthesis.
@nl
P2093
P2860
P356
P1476
DGAT1 is not essential for int ...... tion or chylomicron synthesis.
@en
P2093
Betty J Burri
Jinny S Wong
Joyce J Repa
Kimberly K Buhman
Nada A Abumrad
Robert L Hamilton
Robert V Farese
Scot J Stone
Steven J Smith
P2860
P304
25474-25479
P356
10.1074/JBC.M202013200
P407
P577
2002-04-16T00:00:00Z