Enhanced absorption and growth inhibition with amino acid monoester prodrugs of floxuridine by targeting hPEPT1 transporters.
about
N3-substituted thymidine bioconjugates for cancer therapy and imagingPalladium-mediated dealkylation of N-propargyl-floxuridine as a bioorthogonal oxygen-independent prodrug strategyBioavailability through PepT1: the role of computer modelling in intelligent drug design.Synthesis, chemical and enzymatic hydrolysis, and aqueous solubility of amino acid ester prodrugs of 3-carboranyl thymidine analogs for boron neutron capture therapy of brain tumors.The development of orally administrable gemcitabine prodrugs with D-enantiomer amino acids: enhanced membrane permeability and enzymatic stabilityEnhancing the intestinal absorption of molecules containing the polar guanidino functionality: a double-targeted prodrug approach.Selection of suitable prodrug candidates for in vivo studies via in vitro studies; the correlation of prodrug stability in between cell culture homogenates and human tissue homogenatesSignificance of peptide transporter 1 in the intestinal permeability of valacyclovir in wild-type and PepT1 knockout mice.Transport of drugs by proton-coupled peptide transporters: pearls and pitfalls.The dipeptide monoester prodrugs of floxuridine and gemcitabine-feasibility of orally administrable nucleoside analogs.Transporters, Trojan horses and therapeutics: suitability of bile acid and peptide transporters for drug delivery.Drug-permeability and transporter assays in Caco-2 and MDCK cell lines.Advances in oral delivery of anti-cancer prodrugs.Addition of amino acid moieties to lapatinib increases the anti-cancer effect via amino acid transporters.The feasibility of enzyme targeted activation for amino acid/dipeptide monoester prodrugs of floxuridine; cathepsin D as a potential targeted enzyme.Potential of amino acid/dipeptide monoester prodrugs of floxuridine in facilitating enhanced delivery of active drug to interior sites of tumors: a two-tier monolayer in vitro study.The achievement of mass balance by simultaneous quantification of floxuridine prodrug, floxuridine, 5-fluorouracil, 5-dihydrouracil, α-fluoro-β-ureidopropionate, α-fluoro-β-alanine using LC-MS.Modern prodrug design for targeted oral drug delivery.
P2860
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P2860
Enhanced absorption and growth inhibition with amino acid monoester prodrugs of floxuridine by targeting hPEPT1 transporters.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Enhanced absorption and growth ...... targeting hPEPT1 transporters.
@en
Enhanced absorption and growth ...... targeting hPEPT1 transporters.
@nl
type
label
Enhanced absorption and growth ...... targeting hPEPT1 transporters.
@en
Enhanced absorption and growth ...... targeting hPEPT1 transporters.
@nl
prefLabel
Enhanced absorption and growth ...... targeting hPEPT1 transporters.
@en
Enhanced absorption and growth ...... targeting hPEPT1 transporters.
@nl
P2093
P2860
P1433
P1476
Enhanced absorption and growth ...... targeting hPEPT1 transporters.
@en
P2093
Balvinder S Vig
Chandrasekharan Ramachandran
Gordon L Amidon
John M Hilfinger
Yasuhiro Tsume
P2860
P304
P356
10.3390/MOLECULES13071441
P407
P577
2008-06-28T00:00:00Z