High resolution structures of p-aminobenzamidine- and benzamidine-VIIa/soluble tissue factor: unpredicted conformation of the 192-193 peptide bond and mapping of Ca2+, Mg2+, Na+, and Zn2+ sites in factor VIIa.
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Structural basis of Na+ activation mimicry in murine thrombinStructure of an Fab–Protease Complex Reveals a Highly Specific Non-canonical Mechanism of InhibitionNa+ binding to meizothrombin desF1Mutant N143P Reveals How Na+ Activates ThrombinCrystal structure of prethrombin-1Rigidification of the autolysis loop enhances Na+ binding to thrombinStructural and Functional Studies of γ-Carboxyglutamic Acid Domains of Factor VIIa and Activated Protein C: Role of Magnesium at Physiological CalciumStaphylococcal SplB Serine Protease Utilizes a Novel Molecular Mechanism of ActivationDirect and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics.Ca2+ switches the effect of PS-containing membranes on Factor Xa from activating to inhibiting: implications for initiation of blood coagulationUnderstanding selectivity of hard and soft metal cations within biological systems using the subvalence concept. I. Application to blood coagulation: direct cation-protein electronic effects vs. indirect interactions through water networksFunctional role of residue 193 (chymotrypsin numbering) in serine proteases: influence of side chain length and beta-branching on the catalytic activity of blood coagulation factor XIa.Zinc modulates the interaction of protein C and activated protein C with endothelial cell protein C receptorThe endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors.Engineering kunitz domain 1 (KD1) of human tissue factor pathway inhibitor-2 to selectively inhibit fibrinolysis: properties of KD1-L17R variantEvidence of the E*-E equilibrium from rapid kinetics of Na+ binding to activated protein C and factor Xa.Redesigning allosteric activation in an enzyme.Quantifying vitamin K-dependent holoprotein compaction caused by differential γ-carboxylation using high-pressure size exclusion chromatography.Restricted active site docking by enzyme-bound substrate enforces the ordered cleavage of prothrombin by prothrombinase.Thrombin.Exosites in the substrate specificity of blood coagulation reactions.Structure-Function Relationship of the Interaction between Tissue Factor and Factor VIIa.Tissue Factor Residues That Modulate Magnesium-Dependent Rate Enhancements of the Tissue Factor/Factor VIIa Complex.Atomic-level description of protein-lipid interactions using an accelerated membrane model.Plasma protein S contains zinc essential for efficient activated protein C-independent anticoagulant activity and binding to factor Xa, but not for efficient binding to tissue factor pathway inhibitor.Recent estimates of the structure of the factor VIIa (FVIIa)/tissue factor (TF) and factor Xa (FXa) ternary complex.Proteases as therapeutics.Nanoscale studies of protein-membrane interactions in blood clotting.Structural biology of factor VIIa/tissue factor initiated coagulationContribution of magnesium in binding of factor IXa to the phospholipid surface: implications for vitamin K-dependent coagulation proteins.Role of magnesium in factor XIa catalyzed activation of factor IX: calcium binding to factor IX under physiologic magnesium.A combined structural dynamics approach identifies a putative switch in factor VIIa employed by tissue factor to initiate blood coagulation.Effect of protein disulfide isomerase chaperone activity inhibition on tissue factor activity.Zn2+ mediates high affinity binding of heparin to the αC domain of fibrinogen.The length of the linker between the epidermal growth factor-like domains in factor VIIa is critical for a productive interaction with tissue factor.Tissue factor coagulant function is enhanced by protein-disulfide isomerase independent of oxidoreductase activity.Influence of membrane composition on the enhancement of factor VIIa/tissue factor activity by magnesium ions.Factor VIIa binding to endothelial cell protein C receptor: differences between mouse and human systems.
P2860
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P2860
High resolution structures of p-aminobenzamidine- and benzamidine-VIIa/soluble tissue factor: unpredicted conformation of the 192-193 peptide bond and mapping of Ca2+, Mg2+, Na+, and Zn2+ sites in factor VIIa.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
High resolution structures of ...... and Zn2+ sites in factor VIIa.
@en
High resolution structures of ...... and Zn2+ sites in factor VIIa.
@nl
type
label
High resolution structures of ...... and Zn2+ sites in factor VIIa.
@en
High resolution structures of ...... and Zn2+ sites in factor VIIa.
@nl
prefLabel
High resolution structures of ...... and Zn2+ sites in factor VIIa.
@en
High resolution structures of ...... and Zn2+ sites in factor VIIa.
@nl
P2093
P2860
P356
P1476
High resolution structures of ...... and Zn2+ sites in factor VIIa.
@en
P2093
Amy E Schmidt
Kaillathe Padmanabhan
Madhu S Bajaj
S Paul Bajaj
Sayeh Agah
P2860
P304
24873-24888
P356
10.1074/JBC.M509971200
P407
P577
2006-06-06T00:00:00Z