Comparison of predictability for human pharmacokinetics parameters among monkeys, rats, and chimeric mice with humanised liver.

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Human plasma metabolic profiles of benzydamine, a flavin-containing monooxygenase probe substrate, simulated with pharmacokinetic data from control and humanized-liver mice.Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators

P2860

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Comparison of predictability for human pharmacokinetics parameters among monkeys, rats, and chimeric mice with humanised liver.

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2016 nî lūn-bûn

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2016年の論文

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2016年学术文章

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2016年学术文章

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2016年学术文章

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2016年学术文章

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2016年学术文章

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2016年学术文章

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2016年學術文章

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2016年學術文章

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Comparison of predictability f ...... ric mice with humanised liver.

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Comparison of predictability f ...... ric mice with humanised liver.

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Comparison of predictability f ...... ric mice with humanised liver.

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Comparison of predictability f ...... ric mice with humanised liver.

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Comparison of predictability f ...... ric mice with humanised liver.

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Comparison of predictability f ...... ric mice with humanised liver.

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Comparison of predictability f ...... ric mice with humanised liver.

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Hideki Hirabayashi

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Ikumi Chisaki

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Maki Miyamoto

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Nobuyuki Amano

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Sayaka Nakagawa

http://www.w3.org/2001/XMLSchema#string

Shinji Iwasaki

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P2860

Aldehyde oxidase: an enzyme of emerging importance in drug discovery

The glucuronidation of mycophenolic acid by human liver, kidney and jejunum microsomes

A new approach to predicting human hepatic clearance of CYP3A4 substrates using monkey pharmacokinetic data.

Comprehensive assessment of human pharmacokinetic prediction based on in vivo animal pharmacokinetic data, part 1: volume of distribution at steady state.

Comprehensive assessment of human pharmacokinetic prediction based on in vivo animal pharmacokinetic data, part 2: clearance.

Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes.

Characterization of aldehyde oxidase enzyme activity in cryopreserved human hepatocytes.

Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport.

Prediction of drug clearance by glucuronidation from in vitro data: use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin-activated human liver microsomes.

In vitro evaluation of potential in vivo probes for human flavin-containing monooxygenase (FMO): metabolism of benzydamine and caffeine by FMO and P450 isoforms

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1052-1063

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scholarly article

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10.1080/00498254.2016.1265160

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English

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2016-11-28T00:00:00Z

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27892765

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Comparison of predictability for human pharmacokinetics parameters among monkeys, rats, and chimeric mice with humanised liver.

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P2860

P2860

Comparison of predictability for human pharmacokinetics parameters among monkeys, rats, and chimeric mice with humanised liver.

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