PKA and Epac1 regulate endothelial integrity and migration through parallel and independent pathways.
about
KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progressionRole of EPAC in cAMP-Mediated Actions in Adrenocortical CellsTonic regulation of vascular permeabilityRac1 recruits the adapter protein CMS/CD2AP to cell-cell contacts.Impedance analysis of GPCR-mediated changes in endothelial barrier function: overview and fundamental considerations for stable and reproducible measurementsRecent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC).Vascular endothelial-cadherin stabilizes at cell-cell junctions by anchoring to circumferential actin bundles through alpha- and beta-catenins in cyclic AMP-Epac-Rap1 signal-activated endothelial cells.Spatial regulation of cyclic AMP-Epac1 signaling in cell adhesion by ERM proteins.Protein kinase A phosphorylation of tau-serine 214 reorganizes microtubules and disrupts the endothelial cell barrierRap1 and Rap2 antagonistically control endothelial barrier resistance.Pharmacological activation of Rap1 antagonizes the endothelial barrier disruption induced by exotoxins ExoS and ExoT of Pseudomonas aeruginosa.PDE4 regulates tissue plasminogen activator expression of human brain microvascular endothelial cellsEmerging role of PKA/eNOS pathway in therapeutic angiogenesis for ischaemic tissue diseasesThe ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling.Under construction: building the macromolecular superstructure and signaling components of an electrical synapse.Rasip1 mediates Rap1 regulation of Rho in endothelial barrier function through ArhGAP29.Increased transforming growth factor β contributes to deterioration of refrigerated fresh frozen plasma's effects in vitro on endothelial cells.Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics.Compound 49b Regulates ZO-1 and Occludin Levels in Human Retinal Endothelial Cells and in Mouse Retinal Vasculature.The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function.Regulation of endothelial barrier function by cyclic nucleotides: the role of phosphodiesterases.Transcellular tunnel dynamics: Control of cellular dewetting by actomyosin contractility and I-BAR proteins.Cyclic nucleotide phosphodiesterases (PDEs): coincidence detectors acting to spatially and temporally integrate cyclic nucleotide and non-cyclic nucleotide signals.Interactions between Epac1 and ezrin in the control of endothelial barrier function.Molecular mechanisms of AGE/RAGE-mediated fibrosis in the diabetic heart.Cilostazol strengthens barrier integrity in brain endothelial cells.Rap1 signaling in endothelial barrier control.Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells.Cyclic AMP phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a vascular endothelial cadherin (VE-Cad)-based signaling complex and controls cAMP-mediated vascular permeabilityBeta-Adrenoceptor Activation Reduces Both Dermal Microvascular Endothelial Cell Migration via a cAMP-Dependent Mechanism and Wound Angiogenesis.The presence of alpha-catenin in the VE-cadherin complex is required for efficient transendothelial migration of leukocytesSmall Rho GTPase-mediated actin dynamics at endothelial adherens junctions.Prostaglandin E receptor-4 receptor mediates endothelial barrier-enhancing and anti-inflammatory effects of oxidized phospholipids.The effector and scaffolding proteins AF6 and MUPP1 interact with connexin36 and localize at gap junctions that form electrical synapses in rodent brain.Laminin regulates mouse embryonic stem cell migration: involvement of Epac1/Rap1 and Rac1/cdc42.Cilostazol enhances integrin-dependent homing of progenitor cells by activation of cAMP-dependent protein kinase in synergy with Epac1.The anti-tumor effects of Mfn2 in breast cancer are dependent on promoter DNA methylation, the P21Ras motif and PKA phosphorylation site.
P2860
Q24305208-911E4475-3347-4405-86E4-3D610061CCDBQ26744605-6B58DA89-8166-4AB4-BF79-41C0B9D6B005Q26863424-6FF0C769-7357-4BDE-9E94-7573FF11D8F5Q30156899-B06313EF-5BFF-4A48-89D7-E96C40BEED7BQ30373402-F38138E3-C795-4F8A-AF56-E696DA3BA0A9Q30405298-55239E3B-0312-4202-9DC3-CA75651A1F70Q33647027-00ED6F54-73A6-4D02-95DE-D650D10FD61CQ34139017-74BDB467-D271-40DC-9D76-8E04B03220A3Q34212662-FF735E20-F9C6-418B-821A-F75451A06D15Q34612615-A7A3E019-FE6E-486D-8720-46DA02CA3506Q35439607-D305244D-96CB-474D-8600-E2807ED996F3Q35985145-E8AFE2D4-F602-4E7C-BAC6-B667E1D7B6A0Q36042713-99B873A5-4BE8-4DA6-9701-F9CC659BEF04Q36290218-4CC3DB77-C85D-42EC-A44B-AC38B925EDA9Q36423270-95C0D215-2292-4D33-9662-DE2F66BE928EQ37010549-EDB270B1-3FD1-4F8A-BA11-019DED0D3587Q37148373-0C1D3F1C-FBD2-491A-9419-52D5FB35FFD5Q37420916-8625C646-6664-42E2-B7FF-BC10DE89D6E7Q37600478-EB152B46-5826-434B-832A-667FDC51630BQ37632467-CCCEC227-57E2-4A6E-B9D0-6CD1A204784AQ37893065-AA5B61B0-555D-4F0F-98FF-FD8A145B694DQ38063267-0256407D-C46E-4BA0-B6B6-85F3270DAD76Q38197306-49EF3D1A-AF85-4329-8D65-7E84B7238969Q38197313-480A5648-42A8-49DA-A449-0486FAB38113Q38290105-7861B4DE-CE0D-4424-B9AA-992EC596C2E5Q39229705-5E8DCA18-C631-4BB0-886D-7A68ED703BFAQ40455556-884E30B2-AFEC-4801-82C2-6351E0E1BAF8Q41905179-8D835A65-A904-4E4E-8CB6-901B70DF7A41Q42025999-E8CA3098-A0DC-4136-B066-D005780F7FEEQ42065432-CB8772E0-8DCF-40E5-886D-BA1DD59ADE32Q42637284-99FF532C-D2A2-4D07-9E4A-BBF2943A27D0Q42730760-3247B253-1F06-4632-A0D9-C132BC15E9F7Q46357619-2D0BD6C4-4116-417D-9F01-739FB84B36DCQ48733746-D1E99B54-AD68-4FEE-9A07-813DF8FA0995Q52598198-5483DC50-FE36-430A-B893-F230BE75D89FQ53437333-8E2E5C3A-2015-428A-802D-89A529D38377Q54979646-904E98B0-21F7-4FE6-BC95-AC4BC82E12F9
P2860
PKA and Epac1 regulate endothelial integrity and migration through parallel and independent pathways.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
PKA and Epac1 regulate endothe ...... llel and independent pathways.
@en
PKA and Epac1 regulate endothe ...... llel and independent pathways.
@nl
type
label
PKA and Epac1 regulate endothe ...... llel and independent pathways.
@en
PKA and Epac1 regulate endothe ...... llel and independent pathways.
@nl
prefLabel
PKA and Epac1 regulate endothe ...... llel and independent pathways.
@en
PKA and Epac1 regulate endothe ...... llel and independent pathways.
@nl
P2093
P1476
PKA and Epac1 regulate endothe ...... llel and independent pathways.
@en
P2093
Johannes L Bos
Magdalena J Lorenowicz
Mar Fernandez-Borja
Matthijs R H Kooistra
Peter L Hordijk
P304
P356
10.1016/J.EJCB.2008.05.004
P577
2008-07-16T00:00:00Z