Behavior of T7 RNA polymerase and mammalian RNA polymerase II at site-specific cisplatin adducts in the template DNA.
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Cisplatin ototoxicity and protection: clinical and experimental studiesDNA slip-outs cause RNA polymerase II arrest in vitro: potential implications for genetic instabilityStructure-function studies of the RNA polymerase II elongation complexInhibition of double-strand break non-homologous end-joining by cisplatin adducts in human cell extractsCockayne syndrome group B protein has novel strand annealing and exchange activities.X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adductEvidence that the transcription elongation function of Rpb9 is involved in transcription-coupled DNA repair in Saccharomyces cerevisiae.ELA1 and CUL3 are required along with ELC1 for RNA polymerase II polyubiquitylation and degradation in DNA-damaged yeast cellsAn in vitro method for detecting genetic toxicity based on inhibition of RNA synthesis by DNA lesionsDiverse effects of individual mismatch repair components on transcription-induced CAG repeat instability in human cells.Cross-link structure affects replication-independent DNA interstrand cross-link repair in mammalian cellsBinding of kinetically inert metal ions to RNA: the case of platinum(II).Transcription inhibition by platinum-DNA cross-links in live mammalian cells.Malondialdehyde adducts in DNA arrest transcription by T7 RNA polymerase and mammalian RNA polymerase II.Novel irreversible small molecule inhibitors of replication protein A display single-agent activity and synergize with cisplatinXpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1.Mechanisms and implications of transcription blockage by guanine-rich DNA sequences.Conformation and recognition of DNA modified by a new antitumor dinuclear PtII complex resistant to decomposition by sulfur nucleophiles.3-Methyl-3-deazaadenine, a stable isostere of N3-methyl-adenine, is efficiently bypassed by replication in vivo and by transcription in vitro.Complex cisplatin-double strand break (DSB) lesions directly impair cellular non-homologous end-joining (NHEJ) independent of downstream damage response (DDR) pathwaysThe 3' processing factor CstF functions in the DNA repair responseTranscription blockage by homopurine DNA sequences: role of sequence composition and single-strand breaks.Inhibitory effect of a short Z-DNA forming sequence on transcription elongation by T7 RNA polymerase.Transcription destabilizes triplet repeatsInhibition of transcription by platinum antitumor compoundsPreparation of mammalian expression vectors incorporating site-specifically platinated-DNA lesions.RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motifHost Cell Reactivation and Transcriptional Activation of Carboplatin-Modified BRCA1.Molecular basis of transcriptional fidelity and DNA lesion-induced transcriptional mutagenesis.RNA polymerase II transcriptional fidelity control and its functional interplay with DNA modifications.The Nonbulky DNA Lesions Spiroiminodihydantoin and 5-Guanidinohydantoin Significantly Block Human RNA Polymerase II Elongation in Vitro.G4-forming sequences in the non-transcribed DNA strand pose blocks to T7 RNA polymerase and mammalian RNA polymerase II.Transcription-induced CAG repeat contraction in human cells is mediated in part by transcription-coupled nucleotide excision repair.Dissecting chemical interactions governing RNA polymerase II transcriptional fidelity.Cisplatin-Induced Ototoxicity: Effects, Mechanisms and Protection Strategies.Multiple states of stalled T7 RNA polymerase at DNA lesions generated by platinum anticancer agents.Fate of RNA polymerase II stalled at a cisplatin lesion.RNA polymerase II blockage by cisplatin-damaged DNA. Stability and polyubiquitylation of stalled polymerase.A novel mode for transcription inhibition mediated by PNA-induced R-loops with a model in vitro system.Effects of DNA lesions on the transcription reaction of mitochondrial RNA polymerase: implications for bypass RNA synthesis on oxidative DNA lesions.
P2860
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P2860
Behavior of T7 RNA polymerase and mammalian RNA polymerase II at site-specific cisplatin adducts in the template DNA.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Behavior of T7 RNA polymerase ...... n adducts in the template DNA.
@en
Behavior of T7 RNA polymerase ...... n adducts in the template DNA.
@nl
type
label
Behavior of T7 RNA polymerase ...... n adducts in the template DNA.
@en
Behavior of T7 RNA polymerase ...... n adducts in the template DNA.
@nl
prefLabel
Behavior of T7 RNA polymerase ...... n adducts in the template DNA.
@en
Behavior of T7 RNA polymerase ...... n adducts in the template DNA.
@nl
P2093
P2860
P356
P1476
Behavior of T7 RNA polymerase ...... n adducts in the template DNA.
@en
P2093
John J Turchi
Philip C Hanawalt
Silvia Tornaletti
Steve M Patrick
P2860
P304
35791-35797
P356
10.1074/JBC.M305394200
P407
P577
2003-06-26T00:00:00Z