The 2'-hydroxyl group of the guanosine nucleophile donates a functionally important hydrogen bond in the tetrahymena ribozyme reaction.
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Design and Experimental Evolution of trans-Splicing Group I Intron Ribozymes.An active site rearrangement within the Tetrahymena group I ribozyme releases nonproductive interactions and allows formation of catalytic interactions.Synthesis of 2'-N-methylamino-2'-deoxyguanosine and 2'-N,N-dimethylamino-2'-deoxyguanosine and their incorporation into RNA by phosphoramidite chemistry.8-Azapurines as isosteric purine fluorescent probes for nucleic acid and enzymatic research.A rearrangement of the guanosine-binding site establishes an extended network of functional interactions in the Tetrahymena group I ribozyme active site.Structure and function converge to identify a hydrogen bond in a group I ribozyme active site.Recognition of guanosine by dissimilar tRNA methyltransferases.Phosphorane intermediate vs. leaving group stabilization by intramolecular hydrogen bonding in the cleavage of trinucleoside monophosphates: implications for understanding catalysis by the large ribozymes.Phosphodiester models for cleavage of nucleic acids.Understanding catalysis of phosphate-transfer reactions by the large ribozymes.
P2860
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P2860
The 2'-hydroxyl group of the guanosine nucleophile donates a functionally important hydrogen bond in the tetrahymena ribozyme reaction.
description
2008 nî lūn-bûn
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2008年の論文
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2008年学术文章
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name
The 2'-hydroxyl group of the g ...... tetrahymena ribozyme reaction.
@en
The 2'-hydroxyl group of the g ...... tetrahymena ribozyme reaction.
@nl
type
label
The 2'-hydroxyl group of the g ...... tetrahymena ribozyme reaction.
@en
The 2'-hydroxyl group of the g ...... tetrahymena ribozyme reaction.
@nl
prefLabel
The 2'-hydroxyl group of the g ...... tetrahymena ribozyme reaction.
@en
The 2'-hydroxyl group of the g ...... tetrahymena ribozyme reaction.
@nl
P2093
P356
P1433
P1476
The 2'-hydroxyl group of the g ...... tetrahymena ribozyme reaction
@en
P2093
Joseph A Piccirilli
Raghuvir N Sengupta
Shirshendu K Deb
P304
P356
10.1021/BI8000648
P407
P577
2008-06-24T00:00:00Z