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Structure-based drug design of novel Aurora kinase A inhibitors: structural basis for potency and specificityDesign and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonistsFast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor lead identificationAurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubulesBPR1K653, a novel Aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cellsSynthesis, beta-adrenergic blocking activity and beta-receptor binding affinities of 1-substituted-3-(2-isopropyl-5-methyl-phenoxy)-propan-2-ol oxalatesImpact of Genetic Variations in HIV-1 Tat on LTR-Mediated Transcription via TAR RNA InteractionMechanism of apoptotic induction in human breast cancer cell, MCF-7, by an analog of curcumin in comparison with curcumin--an in vitro and in silico approach.Ligand efficiency based approach for efficient virtual screening of compound libraries.Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification.Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers.Advances in Aurora kinase inhibitor patents.Aurora kinase inhibitor patents and agents in clinical testing: an update (2009-10).Treat cancers by targeting survivin: just a dream or future reality?Aurora kinase inhibitor patents and agents in clinical testing: an update (2011 - 2013).In-silico and in-vitro anti-cancer potential of a curcumin analogue (1E, 6E)-1, 7-di (1H-indol-3-yl) hepta-1, 6-diene-3, 5-dione.P-Glycoprotein Mediated Multidrug Resistance Reversal by Phytochemicals: A Review of SAR & Future Perspective for Drug Design.Anti-influenza drug discovery: identification of an orally bioavailable quinoline derivative through activity- and property-guided lead optimization.Scaffold-hopping strategy: synthesis and biological evaluation of 5,6-fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents.Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and Michael acceptor group for maximal potency.Anti-influenza drug discovery: structure-activity relationship and mechanistic insight into novel angelicin derivatives.Synthesis and evaluation of 3-aroylindoles as anticancer agents: metabolite approach.Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents.Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer.BDMC-A, an analog of curcumin, inhibits markers of invasion, angiogenesis, and metastasis in breast cancer cells via NF-κB pathway--A comparative study with curcumin.Virtual screening of traditional Chinese medicine (TCM) database: identification of fragment-like lead molecules for filariasis target asparaginyl-tRNA synthetase.Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists.Characterization of a new rat urinary metabolite of piperine by LC/NMR/MS studies.Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine Aurora kinase inhibitor.Study of beta-adrenoreceptor antagonistic activity of DPJ 904 in rats.Synthesis of 4-(1-oxo-isoindoline) and 4-(5,6-dimethoxy-1-oxo-isoindoline)-substituted phenoxypropanolamines and their beta1-, beta2-adrenergic receptor binding studies.Aurora kinase A inhibitors: identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold.2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]- 1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.Reversible Testicular Toxicity of Piperine on Male Albino Rats.Ensemble-based virtual screening: identification of a potential allosteric inhibitor of Bcr-Abl.Identification of a novel leukemic-specific splice variant of DNMT3B and its stability.In Silico Investigations of Chemical Constituents of Clerodendrum colebrookianum in the Anti-Hypertensive Drug Targets: ROCK, ACE, and PDE5.PRMT7 Interacts with ASS1 and Citrullinemia Mutations Disrupt the Interaction.Discovery of non-glycoside sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors by ligand-based virtual screening.Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity.
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Mohane S. Coumar
@ast
Mohane S. Coumar
@en
Mohane S. Coumar
@es
Mohane S. Coumar
@nl
Mohane S. Coumar
@sl
type
label
Mohane S. Coumar
@ast
Mohane S. Coumar
@en
Mohane S. Coumar
@es
Mohane S. Coumar
@nl
Mohane S. Coumar
@sl
prefLabel
Mohane S. Coumar
@ast
Mohane S. Coumar
@en
Mohane S. Coumar
@es
Mohane S. Coumar
@nl
Mohane S. Coumar
@sl
P1053
M-5095-2015
P106
P1153
6508154890
P31
P3829
P496
0000-0002-0505-568X