Progress towards development of an amphibian-based thyroid screening assay using Xenopus laevis. Organismal and thyroidal responses to the model compounds 6-propylthiouracil, methimazole, and thyroxine.
about
Fifteen years after "Wingspread"--environmental endocrine disrupters and human and wildlife health: where we are today and where we need to goCurrent perspectives on the use of alternative species in human health and ecological hazard assessmentsThyroid disruption by Di-n-butyl phthalate (DBP) and mono-n-butyl phthalate (MBP) in Xenopus laevisInteractions between chemical and climate stressors: a role for mechanistic toxicology in assessing climate change risksAmphibians used in research and teaching.A review of ecological risk assessment methods for amphibians: Comparative assessment of testing methodologies and available data.Screening chemicals for thyroid-disrupting activity: A critical comparison of mammalian and amphibian models.Alterations along the Hypothalamic-Pituitary-Thyroid Axis of the Zebrafish (Danio rerio) after Exposure to PropylthiouracilEndocrine disruptors and the thyroid gland--a combined in vitro and in vivo analysis of potential new biomarkersThe hypothalamic-pituitary-thyroid (HPT) axis in frogs and its role in frog development and reproduction.Induction of cytochrome P450 family 1 mRNAs and activities in a cell line from the frog Xenopus laevis.Alternatives to in vivo tests to detect endocrine disrupting chemicals (EDCs) in fish and amphibians--screening for estrogen, androgen and thyroid hormone disruption.Thyroid Hormone-disrupting Effects and the Amphibian Metamorphosis Assay.Inhibition of thyroid hormone release from cultured amphibian thyroid glands by methimazole, 6-propylthiouracil, and perchlorate.Ligand-Mediated Receptor Assembly as an End Point for High-Throughput Chemical Toxicity Screening.Relevance weighting of tier 1 endocrine screening endpoints by rank order.Establishment of transactivation assay systems using fish, amphibian, reptilian and human thyroid hormone receptors.Xenopus tropicalis as a test system for developmental and reproductive toxicity.Development of the Larval Amphibian Growth and Development Assay: Effects of benzophenone-2 exposure in Xenopus laevis from embryo to juvenile.Expression of enzymes involved in thyroid hormone metabolism during the early development of Xenopus tropicalis.Thyroid disruption effects of environmental level perfluorooctane sulfonates (PFOS) in Xenopus laevis.Effects of dietary exposure of polycyclic musk HHCB on the metamorphosis of Xenopus laevis.Meeting the common needs of a more effective and efficient testing and assessment paradigm for chemical risk management.Computational toxicology as implemented by the U.S. EPA: providing high throughput decision support tools for screening and assessing chemical exposure, hazard and risk.The colloidal thyroxine (T4) ring as a novel biomarker of perchlorate exposure in the African clawed frog Xenopus laevis.
P2860
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P2860
Progress towards development of an amphibian-based thyroid screening assay using Xenopus laevis. Organismal and thyroidal responses to the model compounds 6-propylthiouracil, methimazole, and thyroxine.
description
2005 nî lūn-bûn
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2005年の論文
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2005年学术文章
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2005年学术文章
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2005年学术文章
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name
Progress towards development o ...... l, methimazole, and thyroxine.
@en
Progress towards development o ...... l, methimazole, and thyroxine.
@nl
type
label
Progress towards development o ...... l, methimazole, and thyroxine.
@en
Progress towards development o ...... l, methimazole, and thyroxine.
@nl
prefLabel
Progress towards development o ...... l, methimazole, and thyroxine.
@en
Progress towards development o ...... l, methimazole, and thyroxine.
@nl
P2093
P2860
P356
P1476
Progress towards development o ...... l, methimazole, and thyroxine.
@en
P2093
Gary W Holcombe
Joseph E Tietge
Joseph J Korte
Kevin M Flynn
Patricia A Kosian
Sigmund J Degitz
P2860
P304
P356
10.1093/TOXSCI/KFI246
P577
2005-07-07T00:00:00Z