Aggregated LDL and lipid dispersions induce lysosomal cholesteryl ester accumulation in macrophage foam cells.
about
Regulation of lipid stores and metabolism by lipophagyp38 mitogen-activated protein kinase (MAPK) promotes cholesterol ester accumulation in macrophages through inhibition of macroautophagy.Trapping of oxidized LDL in lysosomes of Kupffer cells is a trigger for hepatic inflammation.Size- and charge-dependent non-specific uptake of PEGylated nanoparticles by macrophages.Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells.Lysosomal acid lipase: at the crossroads of normal and atherogenic cholesterol metabolismPhytosterols differentially influence ABC transporter expression, cholesterol efflux and inflammatory cytokine secretion in macrophage foam cells.Perilipin1 deficiency in whole body or bone marrow-derived cells attenuates lesions in atherosclerosis-prone mice.High-capacity selective uptake of cholesteryl ester from native LDL during macrophage foam cell formation.Autophagy is associated with cell fate in the process of macrophage-derived foam cells formation and progress.Medical bioremediation of age-related diseases.Degradation and beyond: the macrophage lysosome as a nexus for nutrient sensing and processing in atherosclerosis.Triglyceride alters lysosomal cholesterol ester metabolism in cholesteryl ester-laden macrophage foam cells.Lysosomal cholesterol accumulation: driver on the road to inflammation during atherosclerosis and non-alcoholic steatohepatitis.Self-eating in the plaque: what macrophage autophagy reveals about atherosclerosis.Lysosomal cholesterol accumulation inhibits subsequent hydrolysis of lipoprotein cholesteryl esterEffects of cellular cholesterol loading on macrophage foam cell lysosome acidification.Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase.Autophagy links inflammasomes to atherosclerotic progression.Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K.Cholesterol is a significant risk factor for non-alcoholic steatohepatitis.Cytosolic lipolysis and lipophagy: two sides of the same coin.Severely altered cholesterol homeostasis in macrophages lacking apoE and SR-BI.
P2860
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P2860
Aggregated LDL and lipid dispersions induce lysosomal cholesteryl ester accumulation in macrophage foam cells.
description
2005 nî lūn-bûn
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2005年の論文
@ja
2005年学术文章
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2005年学术文章
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2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
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2005年學術文章
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2005年學術文章
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name
Aggregated LDL and lipid dispe ...... tion in macrophage foam cells.
@en
Aggregated LDL and lipid dispe ...... tion in macrophage foam cells.
@nl
type
label
Aggregated LDL and lipid dispe ...... tion in macrophage foam cells.
@en
Aggregated LDL and lipid dispe ...... tion in macrophage foam cells.
@nl
prefLabel
Aggregated LDL and lipid dispe ...... tion in macrophage foam cells.
@en
Aggregated LDL and lipid dispe ...... tion in macrophage foam cells.
@nl
P2093
P2860
P1476
Aggregated LDL and lipid dispe ...... tion in macrophage foam cells.
@en
P2093
Brian E Cox
Evelyn E Griffin
W Gray Jerome
P2860
P304
P356
10.1194/JLR.M500059-JLR200
P50
P577
2005-07-16T00:00:00Z