Caprazamycins, novel lipo-nucleoside antibiotics, from Streptomyces sp. II. Structure elucidation of caprazamycins.
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Muraymycin nucleoside-peptide antibiotics: uridine-derived natural products as lead structures for the development of novel antibacterial agentsCapturing Biological Activity in Natural Product Fragments by Chemical SynthesisNew antimycobacterial agents in the pre-clinical phase or beyond: recent advances in patent literature (2001-2016).A high-throughput screen for directed evolution of the natural product sulfotransferase LipB.Novel semisynthetic antibiotics from caprazamycins A-G: caprazene derivatives and their antibacterial activity.Characterization of LipL as a non-heme, Fe(II)-dependent α-ketoglutarate:UMP dioxygenase that generates uridine-5'-aldehyde during A-90289 biosynthesis.Biosynthetic origin and mechanism of formation of the aminoribosyl moiety of peptidyl nucleoside antibiotics.Amalgamation of nucleosides and amino acids in antibiotic biosynthesis: discovery of an L-threonine:uridine-5'-aldehyde transaldolase.The muraminomicin biosynthetic gene cluster and enzymatic formation of the 2-deoxyaminoribosyl appendage.The biosynthesis of nitrogen-, sulfur-, and high-carbon chain-containing sugars.Inhibition of the first step in synthesis of the mycobacterial cell wall core, catalyzed by the GlcNAc-1-phosphate transferase WecA, by the novel caprazamycin derivative CPZEN-45Fe(II)-dependent, uridine-5'-monophosphate α-ketoglutarate dioxygenases in the synthesis of 5'-modified nucleosides.Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis.Antimicrobial nucleoside antibiotics targeting cell wall assembly: recent advances in structure-function studies and nucleoside biosynthesis.Construction of an octosyl acid backbone catalyzed by a radical S-adenosylmethionine enzyme and a phosphatase in the biosynthesis of high-carbon sugar nucleoside antibiotics.Challenges and opportunities in developing novel drugs for TB.Update on carbohydrate-containing antibacterial agents.A new arylsulfate sulfotransferase involved in liponucleoside antibiotic biosynthesis in streptomycetes.Formation and attachment of the deoxysugar moiety and assembly of the gene cluster for caprazamycin biosynthesis.Identification and manipulation of the caprazamycin gene cluster lead to new simplified liponucleoside antibiotics and give insights into the biosynthetic pathway.Structure-based gene targeting discovery of sphaerimicin, a bacterial translocase I inhibitorA novel assay of bacterial peptidoglycan synthesis for natural product screening.Bacterial phosphoglycosyl transferases: initiators of glycan biosynthesis at the membrane interface.Function-Oriented Synthesis: How to Design Simplified Analogues of Antibacterial Nucleoside Natural Products?The first structurally analysed nucleic acid building block containing the Reese protecting group: 2'-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]-β-D-(1'R,2'R,3'R,4'R)-uridine.Self-Resistance During Muraymycin Biosynthesis: A Complementary Nucleotidyltransferase and Phosphotransferase with Identical Modification Sites and Distinct Temporal Order.Design, synthesis and biological evaluation of 5'-C-piperidinyl-5'-O-aminoribosyluridines as potential antibacterial agents.5'-Methylene-triazole-substituted-aminoribosyl uridines as MraY inhibitors: synthesis, biological evaluation and molecular modeling.A-90289 A and B, new inhibitors of bacterial translocase I, produced by Streptomyces sp. SANK 60405.Total Synthesis of (−)-Caprazamycin ATotal Synthesis of (−)-Caprazamycin APlatinum catalyzed 7-endo cyclization of internal alkynyl amides and its application to synthesis of the caprazamycin coreControl of 6-Exo and 7-Endo Cyclizations of Alkynylamides using Platinum and Bismuth Catalysts
P2860
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P2860
Caprazamycins, novel lipo-nucleoside antibiotics, from Streptomyces sp. II. Structure elucidation of caprazamycins.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Caprazamycins, novel lipo-nucl ...... elucidation of caprazamycins.
@en
Caprazamycins, novel lipo-nucl ...... elucidation of caprazamycins.
@nl
type
label
Caprazamycins, novel lipo-nucl ...... elucidation of caprazamycins.
@en
Caprazamycins, novel lipo-nucl ...... elucidation of caprazamycins.
@nl
prefLabel
Caprazamycins, novel lipo-nucl ...... elucidation of caprazamycins.
@en
Caprazamycins, novel lipo-nucl ...... elucidation of caprazamycins.
@nl
P2093
P356
P1476
Caprazamycins, novel lipo-nucl ...... elucidation of caprazamycins.
@en
P2093
Hikaru Nakamura
Hiroshi Naganawa
Masayuki Igarashi
Tetsuo Shitara
Toshiaki Miyake
Yoshiaki Takahashi
Yuzuru Akamatsu
P2888
P304
P356
10.1038/JA.2005.41
P577
2005-05-01T00:00:00Z