Marked decrease in specific activity contributes to disease phenotype in two human glucose 6-phosphate dehydrogenase mutants, G6PD(Union) and G6PD(Andalus).

Marked decrease in specific activity contributes to disease phenotype in two human glucose 6-phosphate dehydrogenase mutants, G6PD(Union) and G6PD(Andalus).

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http://www.wikidata.org/entity/Q46641755
What is the role of the second "structural" NADP+-binding site in human glucose 6-phosphate dehydrogenase?A Multi-scale Computational Platform to Mechanistically Assess the Effect of Genetic Variation on Drug Responses in Human Erythrocyte MetabolismAn optimised system for refolding of human glucose 6-phosphate dehydrogenase.The stability of G6PD is affected by mutations with different clinical phenotypes.Coupling between Protein Stability and Catalytic Activity Determines Pathogenicity of G6PD Variants.A trade off between catalytic activity and protein stability determines the clinical manifestations of glucose-6-phosphate dehydrogenase (G6PD) deficiency.Detailed functional analysis of two clinical glucose-6-phosphate dehydrogenase (G6PD) variants, G6PDViangchan and G6PDViangchan+Mahidol: Decreased stability and catalytic efficiency contribute to the clinical phenotype.Functional and Biochemical Characterization of Three Recombinant Human Glucose-6-Phosphate Dehydrogenase Mutants: Zacatecas, Vanua-Lava and Viangchan.Mutations of Glucose-6-Phosphate Dehydrogenase Durham, Santa-Maria and A+ Variants Are Associated with Loss Functional and Structural Stability of the Protein.Cloning, expression, purification and characterization of his-tagged human glucose-6-phosphate dehydrogenase: a simplified method for protein yield.Biochemical Analysis of Two Single Mutants that Give Rise to a Polymorphic G6PD A-Double Mutant.Biochemical Characterization and Structural Modeling of Fused Glucose-6-Phosphate Dehydrogenase-Phosphogluconolactonase from
P2860

Marked decrease in specific activity contributes to disease phenotype in two human glucose 6-phosphate dehydrogenase mutants, G6PD(Union) and G6PD(Andalus).

Item
http://www.wikidata.org/entity/Q46641755
description
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Marked decrease in specific ac ...... G6PD(Union) and G6PD(Andalus).
@en
Marked decrease in specific ac ...... G6PD(Union) and G6PD(Andalus).
@nl
type
label
Marked decrease in specific ac ...... G6PD(Union) and G6PD(Andalus).
@en
Marked decrease in specific ac ...... G6PD(Union) and G6PD(Andalus).
@nl
prefLabel
Marked decrease in specific ac ...... G6PD(Union) and G6PD(Andalus).
@en
Marked decrease in specific ac ...... G6PD(Union) and G6PD(Andalus).
@nl
P1433
P1476
P2093
P304
P31
P356
P433
P478
P577
P5875
P698
P356
P1433
P1476
Marked decrease in specific ac ...... G6PD(Union) and G6PD(Andalus).
@en
P2093
P304
P31
P356
P433
P478
P577
P5875
P698