Non-enzymatic glutathione reactivity and in vitro toxicity: a non-animal approach to skin sensitization.
about
Pyridoxylamine reactivity kinetics as an amine based nucleophile for screening electrophilic dermal sensitizersHaptenation: chemical reactivity and protein bindingA review of the electrophilic reaction chemistry involved in covalent protein binding relevant to toxicity.The critical review of methodologies and approaches to assess the inherent skin sensitization potential (skin allergies) of chemicals. Part I.Drug discovery for a new generation of covalent drugs.Integrated Approaches to Testing and Assessment.In vitro bioassay for reactive toxicity towards proteins implemented for water quality monitoring.Examination of Michael addition reactivity towards glutathione by transition-state calculations.The selective peptide reactivity of chemical respiratory allergens under competitive and non-competitive conditions.Experimental verification of structural alerts for the protein binding of cyclic compounds acting as Michael acceptors.Experimental verification of structural alerts for the protein binding of sulfur-containing compounds.Time-dependence in mixture toxicity with soft-electrophiles: 2. Effects of relative reactivity level on time-dependent toxicity and combined effects for selected Michael acceptors.Prediction of skin sensitization potential using D-optimal design and GA-kNN classification methods.The definition of the applicability domain relevant to skin sensitization for the aromatic nucleophilic substitution mechanism.Respiratory sensitization: toxicological point of view on the available assays.Ampicillin-ester bonded branched polymers: characterization, cyto-, genotoxicity and controlled drug-release behaviour.Stable isotope labeling method for the investigation of protein haptenation by electrophilic skin sensitizers.Reactivity profiling: covalent modification of single nucleophile peptides for skin sensitization risk assessment.
P2860
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P2860
Non-enzymatic glutathione reactivity and in vitro toxicity: a non-animal approach to skin sensitization.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Non-enzymatic glutathione reac ...... pproach to skin sensitization.
@en
Non-enzymatic glutathione reac ...... pproach to skin sensitization.
@nl
type
label
Non-enzymatic glutathione reac ...... pproach to skin sensitization.
@en
Non-enzymatic glutathione reac ...... pproach to skin sensitization.
@nl
prefLabel
Non-enzymatic glutathione reac ...... pproach to skin sensitization.
@en
Non-enzymatic glutathione reac ...... pproach to skin sensitization.
@nl
P2093
P1433
P1476
Non-enzymatic glutathione reac ...... pproach to skin sensitization.
@en
P2093
Aynur O Aptula
David W Roberts
T W Schultz
P304
P356
10.1016/J.TIV.2005.07.003
P577
2005-08-19T00:00:00Z