Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod.
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Talin contains a C-terminal calpain2 cleavage site important in focal adhesion dynamicsStructural mimicry for vinculin activation by IpaA, a virulence factor of Shigella flexneriVinculin binding in its closed conformation by a helix addition mechanismTalin Dependent Mechanosensitivity of Cell Focal AdhesionsThe vinculin-DeltaIn20/21 mouse: characteristics of a constitutive, actin-binding deficient splice variant of vinculinVinculin controls talin engagement with the actomyosin machinery.The structure of the C-terminal actin-binding domain of talinStructural Determinants of Integrin Binding to the Talin RodThe Structure of an Interdomain Complex That Regulates Talin ActivityThe domain structure of talin: Residues 1815-1973 form a five-helix bundle containing a cryptic vinculin-binding siteCentral Region of Talin Has a Unique Fold That Binds Vinculin and ActinIntermolecular versus intramolecular interactions of the vinculin binding site 33 of talinNovel Vinculin Binding Site of the IpaA Invasin of ShigellaThe Rickettsia Surface Cell Antigen 4 Applies Mimicry to Bind to and Activate VinculinRIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and TurnoverCrystal structure of vinculin in complex with vinculin binding site 50 (VBS50), the integrin binding site 2 (IBS2) of talinThe Cytoskeletal Protein -Catenin Unfurls upon Binding to VinculinMolecular dynamics study of talin-vinculin binding.Vinculin is a dually regulated actin filament barbed end-capping and side-binding proteinActomyosin-dependent formation of the mechanosensitive talin-vinculin complex reinforces actin anchoring.How force might activate talin's vinculin binding sites: SMD reveals a structural mechanism.Nanoscale architecture of cadherin-based cell adhesions.Talins and kindlins: partners in integrin-mediated adhesion.A molecular dynamics investigation of vinculin activation.Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1.New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2.Identification of Hic-5 as a novel regulatory factor for integrin αIIbβ3 activation and platelet aggregation in mice.The talin dimer structure orientation is mechanically regulated.Molecular mechanisms of host cytoskeletal rearrangements by Shigella invasins.Vinculin activation is necessary for complete talin bindingIntegrin-mediated internalization of Staphylococcus aureus does not require vinculinThe integrin binding site 2 (IBS2) in the talin rod domain is essential for linking integrin beta subunits to the cytoskeleton.Structural and mechanistic insights into the recruitment of talin by RIAM in integrin signalingThe talin rod IBS2 alpha-helix interacts with the beta3 integrin cytoplasmic tail membrane-proximal helix by establishing charge complementary salt bridges.Talin 2 is a large and complex gene encoding multiple transcripts and protein isoformsThe desmin coil 1B mutation K190A impairs nebulin Z-disc assembly and destabilizes actin thin filaments.New insights into vinculin function and regulation.A conserved lipid-binding loop in the kindlin FERM F1 domain is required for kindlin-mediated αIIbβ3 integrin coactivation.Subcellular localization of talin is regulated by inter-domain interactionsαE-catenin is an autoinhibited molecule that coactivates vinculin.
P2860
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P2860
Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Mapping and consensus sequence ...... ng sites within the talin rod.
@en
Mapping and consensus sequence ...... ng sites within the talin rod.
@nl
type
label
Mapping and consensus sequence ...... ng sites within the talin rod.
@en
Mapping and consensus sequence ...... ng sites within the talin rod.
@nl
prefLabel
Mapping and consensus sequence ...... ng sites within the talin rod.
@en
Mapping and consensus sequence ...... ng sites within the talin rod.
@nl
P2093
P2860
P50
P356
P1476
Mapping and consensus sequence ...... ng sites within the talin rod.
@en
P2093
David R Critchley
Igor L Barsukov
Jonas Emsley
Ronald Frank
P2860
P304
37217-37224
P356
10.1074/JBC.M508060200
P407
P577
2005-08-30T00:00:00Z