The two thrombospondin type I repeat domains of the heparin-binding growth-associated molecule bind to heparin/heparan sulfate and regulate neurite extension and plasticity in hippocampal neurons.
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Structural studies reveal an important role for the pleiotrophin C-terminus in mediating interactions with chondroitin sulfateStructure of pleiotrophin- and hepatocyte growth factor-binding sulfated hexasaccharide determined by biochemical and computational approaches.Selective decline of synaptic protein levels in the frontal cortex of female mice deficient in the extracellular metalloproteinase ADAMTS1.Midkine as a factor to counteract the deposition of amyloid β-peptide plaques: in vitro analysis and examination in knockout mice.Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus.The survival-promoting peptide Y-P30 enhances binding of pleiotrophin to syndecan-2 and -3 and supports its neuritogenic activityN-syndecan deficiency impairs neural migration in brain.Multimodal signaling by the ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) promotes neurite extension.Pleiotrophin exerts its migration and invasion effect through the neuropilin-1 pathwayMidkine and pleiotrophin have bactericidal properties: preserved antibacterial activity in a family of heparin-binding growth factors during evolution.Periadolescent amphetamine treatment causes transient cognitive disruptions and long-term changes in hippocampal LTP depending on the endogenous expression of pleiotrophin.Pleiotrophin, a multifunctional cytokine and growth factor, induces leukocyte responses through the integrin Mac-1.Heparan sulphate proteoglycans in glia and in the normal and injured CNS: expression of sulphotransferases and changes in sulphation
P2860
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P2860
The two thrombospondin type I repeat domains of the heparin-binding growth-associated molecule bind to heparin/heparan sulfate and regulate neurite extension and plasticity in hippocampal neurons.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
The two thrombospondin type I ...... ticity in hippocampal neurons.
@en
The two thrombospondin type I ...... ticity in hippocampal neurons.
@nl
type
label
The two thrombospondin type I ...... ticity in hippocampal neurons.
@en
The two thrombospondin type I ...... ticity in hippocampal neurons.
@nl
prefLabel
The two thrombospondin type I ...... ticity in hippocampal neurons.
@en
The two thrombospondin type I ...... ticity in hippocampal neurons.
@nl
P2093
P2860
P50
P356
P1476
The two thrombospondin type I ...... ticity in hippocampal neurons.
@en
P2093
Anni Hienola
Emilia Klankki
Ilkka Kilpelaïnen
Mari Pekkanen
Nisse Kalkkinen
Sarka Tumova
Tomi Taira
P2860
P304
41576-41583
P356
10.1074/JBC.M506457200
P407
P577
2005-09-09T00:00:00Z