IL-21R on T cells is critical for sustained functionality and control of chronic viral infection.
about
HIV-1-specific interleukin-21+ CD4+ T cell responses contribute to durable viral control through the modulation of HIV-specific CD8+ T cell functionInterleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllersIL-21 Signaling in ImmunityMolecular and cellular insights into T cell exhaustionOvercoming T cell exhaustion in infection and cancerRevealing the role of CD4(+) T cells in viral immunityDistinct roles of CD4+ T cell subpopulations in retroviral immunity: lessons from the Friend virus mouse modelThe role of interleukin-21 in HIV infectionCD4 T-cell immunotherapy for chronic viral infections and cancerEarly Loss of Splenic Tfh Cells in SIV-Infected Rhesus MacaquesMaintenance of intestinal Th17 cells and reduced microbial translocation in SIV-infected rhesus macaques treated with interleukin (IL)-21Crystal Structure of Interleukin-21 Receptor (IL-21R) Bound to IL-21 Reveals That Sugar Chain Interacting with WSXWS Motif Is Integral Part of IL-21RInnate and Adaptive Immune Regulation During Chronic Viral InfectionsImmunology. A chronic need for IL-21IL-21: roles in immunopathology and cancer therapyHuman TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndromeHIV and Tuberculosis: a Deadly Human SyndemicIL-21R signaling suppresses IL-17+ gamma delta T cell responses and production of IL-17 related cytokines in the lung at steady state and after Influenza A virus infection.CD4+ T cells contain early extrapulmonary tuberculosis (TB) dissemination and rapid TB progression and sustain multieffector functions of CD8+ T and CD3- lymphocytes: mechanisms of CD4+ T cell immunity.Anatomy of viral persistence.Type I interferon suppresses de novo virus-specific CD4 Th1 immunity during an established persistent viral infection.CD40 signaling to the rescue: A CD8 exhaustion perspective in chronic infectious diseasesIL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infection.Induction of Gag-specific CD4 T cell responses during acute HIV infection is associated with improved viral control.Shaping successful and unsuccessful CD8 T cell responses following infection.IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumoursPolyfunctional CD4+ T cell responses to a set of pathogenic arenaviruses provide broad population coverageInflammatory cytokines as a third signal for T cell activationOpposing positive and negative regulation of T cell activity during viral persistence.Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1A little 'help' from IL-21 during persistent viral infectionInterleukin-21: a new mediator of inflammation in systemic lupus erythematosus.Immune activation is associated with CD8 T cell interleukin-21 production in HIV-1-infected individuals.Persistence of viral infection despite similar killing efficacy of antiviral CD8(+) T cells during acute and chronic phases of infection.Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection.T-cell exhaustion: characteristics, causes and conversion.Pronounced virus-dependent activation drives exhaustion but sustains IFN-γ transcript levels.Enhancing T Cell Immune Responses by B Cell-based Therapeutic Vaccine Against Chronic Virus Infection.Ex vivo expansion of human CD8+ T cells using autologous CD4+ T cell helpMinimal effect of CD103 expression on the control of a chronic antiviral immune response.
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P2860
IL-21R on T cells is critical for sustained functionality and control of chronic viral infection.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
IL-21R on T cells is critical ...... ol of chronic viral infection.
@en
IL-21R on T cells is critical ...... ol of chronic viral infection.
@nl
type
label
IL-21R on T cells is critical ...... ol of chronic viral infection.
@en
IL-21R on T cells is critical ...... ol of chronic viral infection.
@nl
prefLabel
IL-21R on T cells is critical ...... ol of chronic viral infection.
@en
IL-21R on T cells is critical ...... ol of chronic viral infection.
@nl
P2093
P2860
P50
P356
P1433
P1476
IL-21R on T cells is critical ...... ol of chronic viral infection.
@en
P2093
Abdijapar T Shamshiev
Anja Fröhlich
Benjamin J Marsland
Iwana Schmitz
Jacqueline Weber
P2860
P304
P356
10.1126/SCIENCE.1172815
P407
P577
2009-05-28T00:00:00Z