The crystal structure of leucyl-tRNA synthetase complexed with tRNALeu in the post-transfer-editing conformation.
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A single residue in leucyl-tRNA synthetase affecting amino acid specificity and tRNA aminoacylationPentamidine binds to tRNA through non-specific hydrophobic interactions and inhibits aminoacylation and translationStructural basis for functional mimicry of long-variable-arm tRNA by transfer-messenger RNAConserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signalingMD Simulations of tRNA and Aminoacyl-tRNA Synthetases: Dynamics, Folding, Binding, and AllosteryAn antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing siteUnique protein architecture of alanyl-tRNA synthetase for aminoacylation, editing, and dimerizationModeling of tRNA-assisted mechanism of Arg activation based on a structure of Arg-tRNA synthetase, tRNA, and an ATP analog (ANP)Peripheral insertion modulates the editing activity of the isolated CP1 domain of leucyl-tRNA synthetaseUnveiling the structural basis for translational ambiguity tolerance in a human fungal pathogenLeucyl-tRNA synthetase editing domain functions as a molecular rheostat to control codon ambiguity in Mycoplasma pathogensDiscovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetaseStructural dynamics of the aminoacylation and proofreading functional cycle of bacterial leucyl-tRNA synthetasePlant tumour biocontrol agent employs a tRNA-dependent mechanism to inhibit leucyl-tRNA synthetaseEvolutionary conservation of a functionally important backbone phosphate group critical for aminoacylation of histidine tRNAs.Ancient origin of the divergent forms of leucyl-tRNA synthetases in the HalobacterialestRNA-dependent pre-transfer editing by prokaryotic leucyl-tRNA synthetase.tRNA synthetase: tRNA aminoacylation and beyondThe balance between pre- and post-transfer editing in tRNA synthetases.Self-protective responses to norvaline-induced stress in a leucyl-tRNA synthetase editing-deficient yeast strain.Functional segregation of a predicted "hinge" site within the beta-strand linkers of Escherichia coli leucyl-tRNA synthetasePartitioning of tRNA-dependent editing between pre- and post-transfer pathways in class I aminoacyl-tRNA synthetases.Resampling and editing of mischarged tRNA prior to translation elongation.Characterization of benzoxaborole-based antifungal resistance mutations demonstrates that editing depends on electrostatic stabilization of the leucyl-tRNA synthetase editing cap.Coordination of tRNA synthetase active sites for chemical fidelityCP1-dependent partitioning of pretransfer and posttransfer editing in leucyl-tRNA synthetase.Defects in transient tRNA translocation bypass tRNA synthetase quality control mechanisms.A glycine hinge for tRNA-dependent translocation of editing substrates to prevent errors by leucyl-tRNA synthetase.Modulation of Aminoacylation and Editing Properties of Leucyl-tRNA Synthetase by a Conserved Structural Module.Role of coupled dynamics in the catalytic activity of prokaryotic-like prolyl-tRNA synthetases.Yeast mitochondrial leucyl-tRNA synthetase CP1 domain has functionally diverged to accommodate RNA splicing at expense of hydrolytic editing.Degenerate connective polypeptide 1 (CP1) domain from human mitochondrial leucyl-tRNA synthetase.Kinetic partitioning between synthetic and editing pathways in class I aminoacyl-tRNA synthetases occurs at both pre-transfer and post-transfer hydrolytic stepsIn vitro assays for the determination of aminoacyl-tRNA synthetase editing activity.A Flexible peptide tether controls accessibility of a unique C-terminal RNA-binding domain in leucyl-tRNA synthetases.C-terminal Domain of Leucyl-tRNA Synthetase from Pathogenic Candida albicans Recognizes both tRNASer and tRNALeuCrucial role of the C-terminal domain of Mycobacterium tuberculosis leucyl-tRNA synthetase in aminoacylation and editing.Short peptides from leucyl-tRNA synthetase rescue disease-causing mitochondrial tRNA point mutations.Recognition of tRNALeu by Aquifex aeolicus leucyl-tRNA synthetase during the aminoacylation and editing steps.Structural and functional mapping of the archaeal multi-aminoacyl-tRNA synthetase complex
P2860
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P2860
The crystal structure of leucyl-tRNA synthetase complexed with tRNALeu in the post-transfer-editing conformation.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
The crystal structure of leucy ...... transfer-editing conformation.
@en
The crystal structure of leucy ...... transfer-editing conformation.
@nl
type
label
The crystal structure of leucy ...... transfer-editing conformation.
@en
The crystal structure of leucy ...... transfer-editing conformation.
@nl
prefLabel
The crystal structure of leucy ...... transfer-editing conformation.
@en
The crystal structure of leucy ...... transfer-editing conformation.
@nl
P2860
P50
P356
P1476
The crystal structure of leucy ...... transfer-editing conformation.
@en
P2093
Anna Yaremchuk
P2860
P2888
P304
P356
10.1038/NSMB986
P577
2005-09-11T00:00:00Z