A pilot study on brain-to-plasma partition of 10,11-dyhydro-10-hydroxy-5H-dibenzo(b,f)azepine-5-carboxamide and MDR1 brain expression in epilepsy patients not responding to oxcarbazepine.
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P-gp Protein Expression and Transport Activity in Rodent Seizure Models and Human EpilepsyDrug-Resistant Epilepsy: Multiple Hypotheses, Few AnswersPharmacokinetics and drug interactions of eslicarbazepine acetate.Corpora amylacea deposition in the hippocampus of patients with mesial temporal lobe epilepsy: A new role for an old gene?Multidrug resistance in epilepsy: a pharmacogenomic update.CYP3A5*3 and C3435T MDR1 polymorphisms in prognostication of drug-resistant epilepsy in children and adolescentsOne of the hottest topics in epileptology: ABC proteins. Their inhibition may be the future for patients with intractable seizures.Transporter hypothesis of drug-resistant epilepsy: challenges for pharmacogenetic approaches.Novel and emerging strategies in drug delivery for overcoming the blood-brain barrier.Blood-brain barrier P450 enzymes and multidrug transporters in drug resistance: a synergistic role in neurological diseases.Drug resistance in epilepsy and the ABCB1 gene: The clinical perspective.Epilepsy in patients with a brain tumour: focal epilepsy requires focused treatment.Intractable epilepsy and the P-glycoprotein hypothesis.In vitro transport profile of carbamazepine, oxcarbazepine, eslicarbazepine acetate, and their active metabolites by human P-glycoprotein.Comparison of brain extracellular fluid, brain tissue, cerebrospinal fluid, and serum concentrations of antiepileptic drugs measured intraoperatively in patients with intractable epilepsy.Impact of efflux transporters and of seizures on the pharmacokinetics of oxcarbazepine metabolite in the rat brain.Means, motive, and opportunity: establishing culpability in pharmacoresistant epilepsy.Development of a humanized in vitro blood-brain barrier model to screen for brain penetration of antiepileptic drugs.Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats.
P2860
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P2860
A pilot study on brain-to-plasma partition of 10,11-dyhydro-10-hydroxy-5H-dibenzo(b,f)azepine-5-carboxamide and MDR1 brain expression in epilepsy patients not responding to oxcarbazepine.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年學術文章
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name
A pilot study on brain-to-plas ...... t responding to oxcarbazepine.
@en
A pilot study on brain-to-plas ...... t responding to oxcarbazepine.
@nl
type
label
A pilot study on brain-to-plas ...... t responding to oxcarbazepine.
@en
A pilot study on brain-to-plas ...... t responding to oxcarbazepine.
@nl
prefLabel
A pilot study on brain-to-plas ...... t responding to oxcarbazepine.
@en
A pilot study on brain-to-plas ...... t responding to oxcarbazepine.
@nl
P2093
P2860
P50
P1433
P1476
A pilot study on brain-to-plas ...... t responding to oxcarbazepine.
@en
P2093
Christoph Baumgartner
Giovanna Guiso
Klaus Novak
Massimo Rizzi
Silvio Caccia
Susanne Pirker
Thomas Czech
P2860
P304
P356
10.1111/J.1528-1167.2005.00265.X
P577
2005-10-01T00:00:00Z