Cellular folates prevent polyglutamation of 5, 10-dideazatetrahydrofolate. A novel mechanism of resistance to folate antimetabolites.
about
Methylation-dependent silencing of the reduced folate carrier gene in inherently methotrexate-resistant human breast cancer cells.Resistance to antifolates.Functional loss of the reduced folate carrier enhances the antitumor activities of novel antifolates with selective uptake by the proton-coupled folate transporter.Molecular analysis of murine leukemia cell lines resistant to 5, 10-dideazatetrahydrofolate identifies several amino acids critical to the function of folylpolyglutamate synthetase.Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate.Mutations in the reduced folate carrier gene which confer dominant resistance to 5,10-dideazatetrahydrofolate.Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates.Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake.
P2860
Q34087168-FC1B0F8C-9544-4721-9E16-9482FF7A1B52Q35567272-977D9A95-E228-4E5F-85A5-920A88ADCB15Q36294436-20102A74-70EC-4FA7-854E-32055EA5902DQ40873521-10C41DC6-030B-43FA-9BB9-C7C7F6C7AF39Q42071811-66A74A2A-3E6B-4651-B72D-A604F3FC4BC6Q46061580-5B579449-B913-43C2-B4AD-DF7975A8A717Q52828371-1B1A5506-D00B-4DD9-A3E9-641FA743CC76Q54044175-B9289FA3-B7D9-4FE7-AE6A-DA2FCA07AE8B
P2860
Cellular folates prevent polyglutamation of 5, 10-dideazatetrahydrofolate. A novel mechanism of resistance to folate antimetabolites.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
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1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
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1998年學術文章
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1998年學術文章
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name
Cellular folates prevent polyg ...... nce to folate antimetabolites.
@en
Cellular folates prevent polyg ...... nce to folate antimetabolites.
@nl
type
label
Cellular folates prevent polyg ...... nce to folate antimetabolites.
@en
Cellular folates prevent polyg ...... nce to folate antimetabolites.
@nl
prefLabel
Cellular folates prevent polyg ...... nce to folate antimetabolites.
@en
Cellular folates prevent polyg ...... nce to folate antimetabolites.
@nl
P2860
P356
P1476
Cellular folates prevent polyg ...... nce to folate antimetabolites.
@en
P2860
P304
25944-25952
P356
10.1074/JBC.273.40.25944
P407
P577
1998-10-01T00:00:00Z