Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons.
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Immunization with the SDPM1 peptide lowers amyloid plaque burden and improves cognitive function in the APPswePSEN1(A246E) transgenic mouse model of Alzheimer's disease.Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseasesAmyloids: friend or foe?Mitochondrial Dysfunction in Alzheimer's Disease and the Rationale for Bioenergetics Based TherapiesTargeting the proper amyloid-beta neuronal toxins: a path forward for Alzheimer's disease immunotherapeuticsTransient dynamics of Aβ contribute to toxicity in Alzheimer's diseaseDefects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's diseaseBlockade of gap junction hemichannel suppresses disease progression in mouse models of amyotrophic lateral sclerosis and Alzheimer's diseaseAdvancing translational research with the Semantic WebMolecular Structure of Aggregated Amyloid-β: Insights from Solid-State Nuclear Magnetic ResonanceDisruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid betaFingolimod phosphate attenuates oligomeric amyloid β-induced neurotoxicity via increased brain-derived neurotrophic factor expression in neuronsAmyloid-precursor-protein-lowering small molecules for disease modifying therapy of Alzheimer's diseaseModels of membrane-bound Alzheimer's Abeta peptide assembliesCytoskeletal pathologies of Alzheimer diseaseExploring the mechanism of beta-amyloid toxicity attenuation by multivalent sialic acid polymers through the use of mathematical models.Rapid, concurrent alterations in pre- and postsynaptic structure induced by naturally-secreted amyloid-beta protein.Structural classification of toxic amyloid oligomersMicroglia activated with the toll-like receptor 9 ligand CpG attenuate oligomeric amyloid {beta} neurotoxicity in in vitro and in vivo models of Alzheimer's disease.Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5Plaque-associated lipids in Alzheimer's diseased brain tissue visualized by nonlinear microscopyThe amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy.High-speed atomic force microscopy reveals structural dynamics of amyloid β1-42 aggregates.Fingolimod Limits Acute Aβ Neurotoxicity and Promotes Synaptic Versus Extrasynaptic NMDA Receptor Functionality in Hippocampal NeuronsMitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDsCan oral infection be a risk factor for Alzheimer's disease?Alzheimer's-associated Abeta oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal.Fibrillar oligomers nucleate the oligomerization of monomeric amyloid beta but do not seed fibril formationNicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection.Differential effects of amyloid-β peptide aggregation status on in vivo retinal neurotoxicityA role for thrombospondin-1 deficits in astrocyte-mediated spine and synaptic pathology in Down's syndrome.Transgenic Drosophila models of Alzheimer's disease and tauopathiesCalcium signaling and amyloid toxicity in Alzheimer disease.Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease.Amyloid-beta-induced ion flux in artificial lipid bilayers and neuronal cells: resolving a controversyThe effects of cholesterol on learning and memory.Amyloid-beta peptide and oligomers in the brain and cerebrospinal fluid of aged canines.Development of a novel cellular model of Alzheimer's disease utilizing neurosphere cultures derived from B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J embryonic mouse brainProlonged Abeta treatment leads to impairment in the ability of primary cortical neurons to maintain K+ and Ca2+ homeostasis.Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering
P2860
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P2860
Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Different conformations of amy ...... sms in human cortical neurons.
@en
Different conformations of amy ...... sms in human cortical neurons.
@nl
type
label
Different conformations of amy ...... sms in human cortical neurons.
@en
Different conformations of amy ...... sms in human cortical neurons.
@nl
prefLabel
Different conformations of amy ...... sms in human cortical neurons.
@en
Different conformations of amy ...... sms in human cortical neurons.
@nl
P2093
P1476
Different conformations of amy ...... isms in human cortical neurons
@en
P2093
Atul Deshpande
Charles Glabe
Erene Mina
Jorge Busciglio
P304
P356
10.1523/JNEUROSCI.1189-06.2006
P407
P577
2006-05-01T00:00:00Z