Blood-brain barrier transport helps to explain discrepancies in in vivo potency between oxycodone and morphine.
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Analgesic efficacy, adverse effects, and safety of oxycodone administered as continuous intravenous infusion in patients after total hip arthroplasty.Comparison of a drug versus money and drug versus drug self-administration choice procedure with oxycodone and morphine in opioid addicts.Different effects of morphine and oxycodone in experimentally evoked hyperalgesia: a human translational study.The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics.The UDP-glucuronosyltransferases of the blood-brain barrier: their role in drug metabolism and detoxication.Pain management of the cancer patient.Rapid dopamine transmission within the nucleus accumbens: dramatic difference between morphine and oxycodone delivery.Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G PolymorphismPhysiologically based pharmacokinetic modelling of drug penetration across the blood-brain barrier--towards a mechanistic IVIVE-based approachDantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unitG protein-gated inwardly rectifying potassium (KIR3) channels play a primary role in the antinociceptive effect of oxycodone, but not morphine, at supraspinal sites.Assessing brain free fraction in early drug discovery.Oxycodone for the treatment of postoperative pain.In vitro, in vivo and in silico models of drug distribution into the brain.Oxycodone combined with opioid receptor antagonists: efficacy and safety.The blood-brain barrier: an engineering perspective.Perspectives on Intravenous Oxycodone for Control of Postoperative Pain.Pharmacokinetic and pharmacodynamic evaluation of oxycodone and naltrexone for the treatment of chronic lower back pain.Analgesic concentrations of oxycodone--a prospective clinical PK/PD study in patients with laparoscopic cholecystectomy.Comparing translational population-PBPK modelling of brain microdialysis with bottom-up prediction of brain-to-plasma distribution in rat and human.The opioid epidemic: a central role for the blood brain barrier in opioid analgesia and abuse.Rat brain CYP2D activity alters in vivo central oxycodone metabolism, levels and resulting analgesia.Contribution of oxycodone and its metabolites to the overall analgesic effect after oxycodone administration.In-depth neuropharmacokinetic analysis of antipsychotics based on a novel approach to estimate unbound target-site concentration in CNS regions: link to spatial receptor occupancy.Intravenous Oxycodone versus Intravenous Morphine in Cancer Pain: A Randomized, Open-Label, Parallel-Group, Active-Control Study.Comparison of different methods of postoperative analgesia after thoracotomy-a randomized controlled trial
P2860
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P2860
Blood-brain barrier transport helps to explain discrepancies in in vivo potency between oxycodone and morphine.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Blood-brain barrier transport ...... etween oxycodone and morphine.
@en
Blood-brain barrier transport ...... etween oxycodone and morphine.
@nl
type
label
Blood-brain barrier transport ...... etween oxycodone and morphine.
@en
Blood-brain barrier transport ...... etween oxycodone and morphine.
@nl
prefLabel
Blood-brain barrier transport ...... etween oxycodone and morphine.
@en
Blood-brain barrier transport ...... etween oxycodone and morphine.
@nl
P1433
P1476
Blood-brain barrier transport ...... between oxycodone and morphine
@en
P2093
Emma Boström
Margareta Hammarlund-Udenaes
P304
P356
10.1097/ALN.0B013E318164CF9E
P407
P577
2008-03-01T00:00:00Z