Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice.
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Ataxin-2 regulates RGS8 translation in a new BAC-SCA2 transgenic mouse modelMotor Dysfunctions and Neuropathology in Mouse Models of Spinocerebellar Ataxia Type 2: A Comprehensive Review12q24 locus association with type 1 diabetes: SH2B3 or ATXN2?Ataxin-2 modulates the levels of Grb2 and SRC but not ras signaling.Blubber transcriptome response to acute stress axis activation involves transient changes in adipogenesis and lipolysis in a fasting-adapted marine mammal.Dissociated fear and spatial learning in mice with deficiency of ataxin-2Genetic variance in the spinocerebellar ataxia type 2 (ATXN2) gene in children with severe early onset obesity.Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase--a key enzyme in lacto-neolacto ganglioside synthesisAtaxin-2: From RNA Control to Human Health and DiseaseA phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains.Evaluation of A2BP1 as an obesity gene.ETS1 regulates the expression of ATXN2.ATXN2-CAG42 sequesters PABPC1 into insolubility and induces FBXW8 in cerebellum of old ataxic knock-in mice.Both ubiquitin ligases FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated.Flexible semiparametric analysis of longitudinal genetic studies by reduced rank smoothing.Generation of human-induced pluripotent stem cells to model spinocerebellar ataxia type 2 in vitro.Cell size and fat content of dietary-restricted Caenorhabditis elegans are regulated by ATX-2, an mTOR repressor.Drosophila ataxin-2 gene encodes two differentially expressed isoforms and its function in larval fat body is crucial for development of peripheral tissuesA comprehensive review of spinocerebellar ataxia type 2 in Cuba.Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice.Genetic ablation of ataxin-2 increases several global translation factors in their transcript abundance but decreases translation rate.Dysregulated expression of lipid storage and membrane dynamics factors in Tia1 knockout mouse nervous tissue.ATAXIN-2 activates PERIOD translation to sustain circadian rhythms in Drosophila.Atxn2 Knockout and CAG42-Knock-in Cerebellum Shows Similarly Dysregulated Expression in Calcium Homeostasis Pathway.Ataxin-2 (Atxn2)-Knock-Out Mice Show Branched Chain Amino Acids and Fatty Acids Pathway Alterations.Mammalian ataxin-2 modulates translation control at the pre-initiation complex via PI3K/mTOR and is induced by starvation.PINK1 and Ataxin-2 as modifiers of growth.Gene co-expression network analysis for identifying modules and functionally enriched pathways in SCA2.A strategy for multimodal data integration: application to biomarkers identification in spinocerebellar ataxia.Impact of Ataxin-2 knock out on circadian locomotor behavior and PER immunoreaction in the SCN of mice.Biology and Pathobiology of TDP-43 and Emergent Therapeutic Strategies.Spinocerebellar ataxia type 2: Measures of saccade changes improve power for clinical trials.Fecundity in ALS
P2860
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P2860
Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice.
@en
Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice.
@nl
type
label
Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice.
@en
Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice.
@nl
prefLabel
Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice.
@en
Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice.
@nl
P2093
P356
P1476
Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice
@en
P2093
Dieter Lütjohann
Edith Hintermann
Georg Auburger
Jana Buchmann
Joachim Nowock
Konrad Sandhoff
Mekhman Azizov
Susanne Brodesser
P304
P356
10.1093/HMG/DDN035
P577
2008-02-04T00:00:00Z