Comparison of pH dependencies of the Tetrahymena ribozyme reactions with RNA 2'-substituted and phosphorothioate substrates reveals a rate-limiting conformational step.
about
Efficient trans-cleavage of a stem-loop RNA substrate by a ribozyme derived from neurospora VS RNAFunctional identification of catalytic metal ion binding sites within RNA.A manganese-dependent ribozyme in the 3'-untranslated region of Xenopus Vg1 mRNAConserved thermochemistry of guanosine nucleophile binding for structurally distinct group I ribozymesA second catalytic metal ion in group I ribozyme.Catalytic activity as a probe of native RNA foldingAn unconventional origin of metal-ion rescue and inhibition in the Tetrahymena group I ribozyme reaction.A kinetic and thermodynamic framework for the Azoarcus group I ribozyme reaction.A novel mechanism for protein-assisted group I intron splicing.Dissection of a metal-ion-mediated conformational change in Tetrahymena ribozyme catalysisExtraordinarily slow binding of guanosine to the Tetrahymena group I ribozyme: implications for RNA preorganization and functionEvidence for proton transfer in the rate-limiting step of a fast-cleaving Varkud satellite ribozyme.Exploring purine N7 interactions via atomic mutagenesis: the group I ribozyme as a case study.An active site rearrangement within the Tetrahymena group I ribozyme releases nonproductive interactions and allows formation of catalytic interactions.Identification of catalytic metal ion ligands in ribozymes.Specificity from steric restrictions in the guanosine binding pocket of a group I ribozyme.The two steps of group II intron self-splicing are mechanistically distinguishable.Metal ion interaction with cosubstrate in self-splicing of group I introns.pH dependence of self-splicing by the group IA2 intron in a pre-mRNA derived from the nrdB gene of bacteriophage T4.Probing the role of a secondary structure element at the 5'- and 3'-splice sites in group I intron self-splicing: the tetrahymena L-16 ScaI ribozyme reveals a new role of the G.U pair in self-splicingFunctional identification of ligands for a catalytic metal ion in group I intronsThe linear form of a group II intron catalyzes efficient autocatalytic reverse splicing, establishing a potential for mobility.Efficient control of group I intron ribozyme catalysis by DNA constraints.Phosphorane intermediate vs. leaving group stabilization by intramolecular hydrogen bonding in the cleavage of trinucleoside monophosphates: implications for understanding catalysis by the large ribozymes.Kinetic characterization of the first step of the ribozyme-catalyzed trans excision-splicing reaction.
P2860
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P2860
Comparison of pH dependencies of the Tetrahymena ribozyme reactions with RNA 2'-substituted and phosphorothioate substrates reveals a rate-limiting conformational step.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年学术文章
@wuu
1994年学术文章
@zh
1994年学术文章
@zh-cn
1994年学术文章
@zh-hans
1994年学术文章
@zh-my
1994年学术文章
@zh-sg
1994年學術文章
@yue
1994年學術文章
@zh-hant
name
Comparison of pH dependencies ...... -limiting conformational step.
@en
Comparison of pH dependencies ...... -limiting conformational step.
@nl
type
label
Comparison of pH dependencies ...... -limiting conformational step.
@en
Comparison of pH dependencies ...... -limiting conformational step.
@nl
prefLabel
Comparison of pH dependencies ...... -limiting conformational step.
@en
Comparison of pH dependencies ...... -limiting conformational step.
@nl
P356
P1433
P1476
Comparison of pH dependencies ...... -limiting conformational step.
@en
P2093
P304
P356
10.1021/BI00183A036
P407
P577
1994-05-01T00:00:00Z