RNA-directed agent, cordycepin, induces cell death in multiple myeloma cells.
about
Aberrant, differential and bidirectional regulation of the unfolded protein response towards cell survival by 3'-deoxyadenosine8-Amino-adenosine inhibits multiple mechanisms of transcription.Chain termination and inhibition of mammalian poly(A) polymerase by modified ATP analoguesPolyadenylation inhibition by the triphosphates of deoxyadenosine analogues.Cordycepin induces apoptosis by enhancing JNK and p38 kinase activity and increasing the protein expression of Bcl-2 pro-apoptotic moleculesCordycepin regulates GSK-3β/β-catenin signaling in human leukemia cellsApoptosis and inhibition of proliferation of cancer cells induced by cordycepinTargeting MET kinase with the small-molecule inhibitor amuvatinib induces cytotoxicity in primary myeloma cells and cell lines.Transcription inhibition as a therapeutic target for cancerCordycepin inhibits protein synthesis and cell adhesion through effects on signal transduction.Separation of cordycepin from Cordyceps militaris fermentation supernatant using preparative HPLC and evaluation of its antibacterial activity as an NAD(+)-dependent DNA ligase inhibitor.The nucleoside antagonist cordycepin causes DNA double strand breaks in breast cancer cells.Cordycepin as a sensitizer to tumour necrosis factor (TNF)-α-induced apoptosis through eukaryotic translation initiation factor 2α (eIF2α)- and mammalian target of rapamycin complex 1 (mTORC1)-mediated inhibition of nuclear factor (NF)-κB.Cordycepin (3'-deoxyadenosine), an inhibitor of mRNA polyadenylation, suppresses proliferation and activates apoptosis in human epithelial endometriotic cells in vitro.MLH1-deficient HCT116 colon tumor cells exhibit resistance to the cytostatic and cytotoxic effect of the poly(A) polymerase inhibitor cordycepin (3'-deoxyadenosine) in vitro.Cordycepin confers neuroprotection in mice models of intracerebral hemorrhage via suppressing NLRP3 inflammasome activation.Pharmacological and therapeutic potential of Cordyceps with special reference to Cordycepin.Cordycepin induces apoptosis of human ovarian cancer cells by inhibiting CCL5-mediated Akt/NF-κB signaling pathway.
P2860
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P2860
RNA-directed agent, cordycepin, induces cell death in multiple myeloma cells.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
RNA-directed agent, cordycepin, induces cell death in multiple myeloma cells.
@en
RNA-directed agent, cordycepin, induces cell death in multiple myeloma cells.
@nl
type
label
RNA-directed agent, cordycepin, induces cell death in multiple myeloma cells.
@en
RNA-directed agent, cordycepin, induces cell death in multiple myeloma cells.
@nl
prefLabel
RNA-directed agent, cordycepin, induces cell death in multiple myeloma cells.
@en
RNA-directed agent, cordycepin, induces cell death in multiple myeloma cells.
@nl
P2093
P2860
P1476
RNA-directed agent, cordycepin, induces cell death in multiple myeloma cells.
@en
P2093
Christine M Stellrecht
Lisa S Chen
Varsha Gandhi
P2860
P304
P356
10.1111/J.1365-2141.2007.06955.X
P407
P577
2008-01-18T00:00:00Z