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Use of Steric Interactions To Control Peptide Turn Geometry. Synthesis of Type VI beta-Turn Mimics with 5-tert-Butylproline.Effect of sequence on peptide geometry in 5-tert-butylprolyl type VI beta-turn mimics.Site-specific protein propargylation using tissue transglutaminase.Synthesis of a new pi-deficient phenylalanine derivative from a common 1,4-diketone intermediate and study of the influence of aromatic density on prolyl amide isomer population.Preparation, characterization, and application of poly(vinyl alcohol)-graft-poly(ethylene glycol) resins: novel polymer matrices for solid-phase synthesis.Three-step solution-phase combinatorial access to 1,2-disubstituted and 1,2,5-trisubstituted pyrroles from carboxylic esters.Deazapurine solid-phase synthesis: combinatorial synthesis of a library of N3,N5,C6-trisubstituted pyrrolo[3,2-d]pyrimidine derivatives on cross-linked polystyrene bearing a cysteamine linker.Solid-phase synthesis of 3-aminopyrrole-2,5-dicarboxylate analogues.Poly(vinyl alcohol)-graft-poly(ethylene glycol) resins and their use in solid-phase synthesis and supported TEMPO catalysis.Pyrrolo[3,2-e][1,4]diazepin-2-one synthesis: a head-to-head comparison of soluble versus insoluble supports.Modified peptide monolayer binding His-tagged biomolecules for small ligand screening with SPR biosensors.A novel biased allosteric compound inhibitor of parturition selectively impedes the prostaglandin F2alpha-mediated Rho/ROCK signaling pathwayDiversity-oriented synthesis of azapeptides with basic amino acid residues: aza-lysine, aza-ornithine, and aza-arginine.Synthesis and alkylation of Aza-Gly-Pro building blocks of peptidomimetic libraries for developing prostaglandin F2α receptor modulators as therapeutics to inhibit preterm labor.De Novo Conception of Small Molecule Modulators Based on Endogenous Peptide Ligands: Pyrrolodiazepin-2-one γ-Turn Mimics That Differentially Modulate Urotensin II Receptor-Mediated Vasoconstriction ex Vivo.Restoration of renal function by a novel prostaglandin EP4 receptor-derived peptide in models of acute renal failure.Azapeptides and their therapeutic potential.Design, synthesis, conformational analysis and application of indolizidin-2-one dipeptide mimics.A critical role of interleukin-1 in preterm labor.Novel Noncompetitive IL-1 Receptor-Biased Ligand Prevents Infection- and Inflammation-Induced Preterm Birth.Design and synthesis of novel azapeptide activators of apoptosis mediated by caspase-9 in cancer cells.Photolabeling of tissue transglutaminase reveals the binding mode of potent cinnamoyl inhibitors.Calcitonin gene-related peptide analogues with aza and indolizidinone amino acid residues reveal conformational requirements for antagonist activity at the human calcitonin gene-related peptide 1 receptor.Antenatal Suppression of IL-1 Protects against Inflammation-Induced Fetal Injury and Improves Neonatal and Developmental Outcomes in Mice.Synthesis and evaluation of 4-(1-aminoalkyl)-N-(4-pyridyl)cyclohexanecarboxamides as Rho kinase inhibitors and neurite outgrowth promoters.N-Amino-imidazolin-2-one peptide mimic synthesis and conformational analysis.Targeting the prostaglandin F2α receptor for preventing preterm labor with azapeptide tocolytics.Aza-1,2,3-triazole-3-alanine synthesis via copper-catalyzed 1,3-dipolar cycloaddition on aza-progargylglycine.Copper-catalyzed N-arylation of semicarbazones for the synthesis of aza-arylglycine-containing aza-peptides.Solution-phase submonomer diversification of aza-dipeptide building blocks and their application in aza-peptide and aza-DKP synthesis.alpha-Amino-beta-hydroxy-gamma-lactam for constraining peptide Ser and Thr residue conformation.Insertion of multiple alpha-amino gamma-lactam (Agl) residues into a peptide sequence by solid-phase synthesis on synphase lanterns.Small-molecule ligands of GD2 ganglioside, designed from NMR studies, exhibit induced-fit binding and bioactivity.Fluorometric assay for tissue transglutaminase-mediated transamidation activity.Mimicry of peptide backbone geometry and heteroatomic side-chain functionality: synthesis of enantiopure indolizidin-2-one amino acids possessing alcohol, acid, and azide functional groups.Synthesis of enantiopure 7-[3-azidopyl]indolizidin-2-one amino acid. A constrained mimic of the peptide backbone geometry and heteroatomic side-chain functionality of the ala-lys dipeptide.SPOCC-194, a new high functional group density PEG-based resin for solid-phase organic synthesis.Serine as chiral educt for the practical synthesis of enantiopure N-protected beta-hydroxyvaline.Diversity-oriented synthesis of functionalized pyrrolo[3,2-d]pyrimidines with variation of the pyrimidine ring nitrogen substituents.Examination of the potential for adaptive chirality of the nitrogen chiral center in aza-aspartame.
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description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
William D. Lubell
@ast
William D. Lubell
@en
William D. Lubell
@es
William D. Lubell
@nl
William D. Lubell
@sl
type
label
William D. Lubell
@ast
William D. Lubell
@en
William D. Lubell
@es
William D. Lubell
@nl
William D. Lubell
@sl
prefLabel
William D. Lubell
@ast
William D. Lubell
@en
William D. Lubell
@es
William D. Lubell
@nl
William D. Lubell
@sl
P108
P106
P1153
7004290660
P21
P2798
P31
P496
0000-0002-3080-2712