Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines. - Wikidata - awgldk - TriplyDB

Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines.

Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines.

http://www.wikidata.org/entity/Q46807874

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GABA A receptors: subtypes provide diversity of function and pharmacology International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update The anti-convulsant stiripentol acts directly on the GABA(A) receptor as a positive allosteric modulator Anxioselective anxiolytics: on a quest for the Holy Grail Molecular mechanisms of antiseizure drug activity at GABAA receptors Targeting the restricted α-subunit repertoire of airway smooth muscle GABAA receptors augments airway smooth muscle relaxation GABAA receptor subtypes: Therapeutic potential in Down syndrome, affective disorders, schizophrenia, and autism.Benzodiazepine-induced anxiolysis and reduction of conditioned fear are mediated by distinct GABAA receptor subtypes in mice Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes.Glutamatergic and GABAergic modulations of ultrasonic vocalizations during maternal separation distress in mouse pups.Prenatal malnutrition alters diazepam-mediated suppression of ultrasonic vocalizations in an age dependent manner.Pharmacological Properties of DOV 315,090, an ocinaplon metabolite.Hooked on benzodiazepines: GABAA receptor subtypes and addiction.Discriminative stimulus effects of L-838,417 (7-tert-butyl-3-(2,5-difluoro-phenyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-[1,2,4]triazolo[4,3-b]pyridazine): role of GABA(A) receptor subtypes.Cocaine effects on mouse incentive-learning and human addiction are linked to alpha2 subunit-containing GABAA receptors.Novel positive allosteric modulators of GABAA receptors: do subtle differences in activity at alpha1 plus alpha5 versus alpha2 plus alpha3 subunits account for dissimilarities in behavioral effects in rats?Valerenic acid derivatives as novel subunit-selective GABAA receptor ligands - in vitro and in vivo characterization.α2-containing GABA(A) receptors: a target for the development of novel treatment strategies for CNS disorders.Influence of GABA(A) receptor α subunit isoforms on the benzodiazepine binding site SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3, α5, or α6 subunit subtypes coexpressed with β3 and γ2 subunits.The external globus pallidus: progress and perspectives GABAA receptor subtype involvement in addictive behaviour.Effect of genetic and pharmacological blockade of GABA receptors on the 5-HT2C receptor function during stress.Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands.Are GABAA receptors containing alpha5 subunits contributing to the sedative properties of benzodiazepine site agonists?The effects of stiripentol on GABA(A) receptors Emergence of anti-conflict effects of zolpidem in rhesus monkeys following extended post-injection intervals.The role of GABA(A) receptors in the development of alcoholism GABA(A) receptor subtype-selective efficacy: TPA023, an alpha2/alpha3 selective non-sedating anxiolytic and alpha5IA, an alpha5 selective cognition enhancer.Contribution of GABA(A) receptors containing α3 subunits to the therapeutic-related and side effects of benzodiazepine-type drugs in monkeys.Long-term behavioral programming induced by peripuberty stress in rats is accompanied by GABAergic-related alterations in the Amygdala.Lifelong CRF overproduction is associated with altered gene expression and sensitivity of discrete GABA(A) and mGlu receptor subtypes.Anxiety and depression: mouse genetics and pharmacological approaches to the role of GABA(A) receptor subtypes.Evidence of zolpidem abuse and dependence: results of the French Centre for Evaluation and Information on Pharmacodependence (CEIP) network survey.Differential roles of GABA(A) receptor subtypes in benzodiazepine-induced enhancement of brain-stimulation reward Search for α3β₂/₃γ2 subtype selective ligands that are stable on human liver microsomes Assessment of subunit-dependent direct gating and allosteric modulatory effects of carisoprodol at GABA(A) receptors.GABAA receptors as targets for novel anxiolytic drugs.Molecular regulation of cognitive functions and developmental plasticity: impact of GABAA receptors.Reinforcing effects of compounds lacking intrinsic efficacy at α1 subunit-containing GABAA receptor subtypes in midazolam- but not cocaine-experienced rhesus monkeys.

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P2860

Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines.

http://www.wikidata.org/entity/Q46807874

description

2005 nî lūn-bûn

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Evidence for a significant rol ...... ic effects of benzodiazepines.

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Evidence for a significant rol ...... ic effects of benzodiazepines.

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Evidence for a significant rol ...... ic effects of benzodiazepines.

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Evidence for a significant rol ...... ic effects of benzodiazepines.

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Evidence for a significant rol ...... ic effects of benzodiazepines.

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Evidence for a significant rol ...... ic effects of benzodiazepines.

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Elizabeth M Garrett

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10.1523/JNEUROSCI.1166-05.2005

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