about
Structural and mechanistic basis of pre- and posttransfer editing by leucyl-tRNA synthetaseNeoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosidesSustainable synthesis and automated deposition: an accessible discovery screening library of fragment-like purines.Tractable synthesis of multipurpose screening compounds with under-represented molecular features for an open access screening platform.Substituted tetrazoles as multipurpose screening compounds.Polymer-assisted solution-phase synthesis of 2'-amido-2'-deoxyadenosine derivatives targeted at the NAD(+)-binding sites of parasite enzymes.1,2,4-trisubstituted cyclopentanes as platforms for diversity.4-Aminocyclopentane-1,3-diols as platforms for diversity: synthesis of anandamide analogs.Advances in the design of a multipurpose fragment screening library.N-acyl-N-alkyl-sulfonamide anchors derived from Kenner's safety-catch linker: powerful tools in bioorganic and medicinal chemistry.Three-Component Aminoalkylations Yielding Dihydronaphthoxazine-Based Sirtuin Inhibitors: Scaffold Modification and Exploration of Space for Polar Side-Chains.Oxidation potentials of N-modified derivatives of the analgesic flupirtine linked to potassium KV 7 channel opening activity but not hepatocyte toxicity.Towards a European strategy for medicines research (2014-2020): The EUFEPS position paper on Horizon 2020.A timely reassessment of early prediction in the bioavailability of orally administered drugs.Inhibitors of adenosine consuming parasites through polymer-assisted solution phase synthesis of lipophilic 5'-amido-5'-deoxyadenosine derivatives.Synthesis and antiplasmodial activity of new N-[3-(4-{3-[(7-chloroquinolin-4-yl)amino]propyl}piperazin-1-yl)propyl]carboxamides.Synthesis of a hydrolytically stable, fluorescent-labeled ATP analog as a tool for probing adenylyl cyclases.Microwave-assisted synthesis and evaluation of acylhydrazones as potential inhibitors of bovine glutathione peroxidase.Improving an antitrypanosomal lead applying nucleophilic substitution on a safety catch linker.Anti-malarial activity of N(6)-substituted adenosine derivatives. Part I.5'-Deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N(6)-cyclopentyladenine: new adenosine A(1) receptor antagonists and inverse agonists.Antimalarial activity of n(6)-substituted adenosine derivatives (part 2).Synthesis and antimalarial activity of novel N6-substituted adenosine derivatives.Evaluation of (S)- and (R)-misonidazole as GPX inhibitors: synthesis, characterization including circular dichroism and in vitro testing on bovine GPx-1.Antimalarial activity of N(6)-substituted adenosine derivatives. Part 3.Polymer-bound reagents for the introduction of spacer-modified biotin labels.Practical synthesis of fenbufen ethanolamide.Parallel synthesis and dopamine D3/D2 receptor screening of novel {4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}carboxamides.Inhibitors of adenosine consuming parasites through polymer-assisted N-acylation of N6-substituted 5'-amino-5'-deoxyadenosines.Parallel synthesis of a series of non-functional ATP/NAD analogs with activity against trypanosomatid parasites.[Calcium salts: fantastic and enlightening].Synthesis of a series of N6-substituted adenosines with activity against trypanosomatid parasites.Towards new antimalarial drugs: synthesis of non-hydrolyzable phosphate mimics as feed for a predictive QSAR study on 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors.Synthesis of beta- and gamma-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates.Quantitative chiral and achiral determination of ketamine and its metabolites by LC-MS/MS in human serum, urine and fecal samples.Ketamine metabolites with antidepressant effects: Fast, economical, and eco-friendly enantioselective separation based on supercritical-fluid chromatography (SFC) and single quadrupole MS detection.G-Protein-Coupled Receptors: Sustained Signaling via Intracellular Megaplexes and Pathway-Specific Drugs.Exploration of the effect of sterically demanding 3'-amido substitution of 3'-deoxyadenosines towards inhibition of cyclin-dependent kinase 1.Supercritical fluid extraction (SFE) of ketamine metabolites from dried urine and on-line quantification by supercritical fluid chromatography and single mass detection (on-line SFE-SFC-MS).Tetrazolylhydrazides as Selective Fragment-Like Inhibitors of the JumonjiC-Domain-Containing Histone Demethylase KDM4A.
P50
Q27641080-E4BD6CFA-B0E4-4135-AA44-A166A3AD5E21Q28364092-5D21BE4C-68EE-4BA3-93F9-2D441609FBC6Q30485636-6B4450CD-A019-47B0-BF0C-58FD13B00F9AQ30486847-0DAC8292-6E35-4468-9054-6F5D672CC7B0Q30490583-2E7CC9C1-EB40-4AEB-B104-C7C0D30D3872Q31455290-207C745A-71FE-493B-8087-71D27BD57453Q34325322-F77D3FF0-D55D-45AB-9FDD-DF740FB92E60Q34479607-9A34298A-0BA6-40E0-A3C7-E159C078DB07Q34616596-8F0F6B92-2055-470D-BFC8-DE9CEFAA4E69Q36011055-D55C93B2-F024-476D-BA45-9DE2614A3FEFQ38761992-5A34D58F-29F4-4CF9-9391-B224FA6B80B2Q38940792-0E4430E0-F053-4B23-96E6-28CE89295321Q39539956-DC844D0D-AC5D-40BF-9CF3-A7E0A61AED7EQ40410324-EB790DEA-0ACC-4429-BAB6-1E5A520D665AQ41939205-E9019A6E-0D5B-4B6B-8906-657A2C632EB8Q41943663-38610033-95AC-4532-BBAD-BBB8566145F4Q43241984-64DAE871-89CD-4227-840B-98149DA396B1Q43650912-E8CF6DB2-C5F8-4335-8526-823E31584984Q43819233-FAC9E455-A77E-48CE-B957-47770457DF8DQ43869150-840485FE-B637-4DC5-A647-18FE40AE9627Q43963989-B38C996B-B859-4196-B8B8-AF7FF158B99FQ44051521-7D11B681-FAEC-4E79-87B3-4AA09A8F7DFFQ44622012-1BEFE575-AB3C-4425-BCC8-0A641120161BQ44643692-C565DE4E-24B7-4E14-BFBC-15E3E452E8A0Q44753916-42C0C7EF-D0C0-418C-992C-A7272EBD00E0Q44895444-9893CDF0-23A1-429B-9FE1-3F125CC8B895Q45099996-9F3D4ABA-E180-43F6-92AC-DACDF5A86778Q45280212-4F8C7225-9673-40FF-A77B-4B90C2EE1832Q45951678-18F54459-8FB0-420A-9E0D-3CC39B79D61BQ45988633-043D56F3-1A46-418E-A640-7DE220310845Q46035461-AD985969-A972-4595-A0D8-9BA603DD4171Q46088618-EF4F9FA2-7075-4CDA-B935-2FF5A97DAB94Q46637366-D7AD0B99-7AE3-41FC-87F4-A7DBD71B3B76Q46833973-E8ECA653-CF42-46B6-AA6F-DAE88A2D7458Q47321506-73BB0223-E72F-4F39-B5E5-8A3936F572D2Q47764817-8AC3E7F4-26C8-41B7-97EA-590513D10647Q48038303-0FB4CE3A-6D9B-42FF-A8DA-2FB804CCD2E4Q48905993-7FBBBC22-5566-4F9C-9261-5FAA5BEF3B6BQ50185978-83349229-D7E9-4551-9F0F-18F16D363342Q53551856-8BA2688D-1704-4E2B-97A7-764199A13F8B
P50
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P1053
H-5067-2013
P106
P21
P31
P3829
P496
0000-0003-1262-6636