Synthesis of a novel series of bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase.

Synthesis of a novel series of bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase.

Item
http://www.wikidata.org/entity/Q46840644
A comprehensive evaluation of the efficacy of leading oxime therapies in guinea pigs exposed to organophosphorus chemical warfare agents or pesticides.Design, evaluation and structure-activity relationship studies of the AChE reactivators against organophosphorus pesticides.SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides.In Vitro Comparison of Two Most Promising H-Oximes (HI-6 and HLö-7) and Currently Commercially Available Reactivators Pralidoxime and Obidoxime in Reactivation of Cyclosarin-Inhibited Human Cholinesterases.In vitro ability of currently available oximes to reactivate organophosphate pesticide-inhibited human acetylcholinesterase and butyrylcholinesterase.Reactivation kinetics of 31 structurally different bispyridinium oximes with organophosphate-inhibited human butyrylcholinesterase.A comparison of the reactivating and therapeutic efficacy of newly developed oximes (K347, K628) with commonly used oximes (obidoxime, HI-6) against tabun in rats and mice.In vitro oxime-assisted reactivation of paraoxon-inhibited human acetylcholinesterase and butyrylcholinesterase.Targeted synthesis of 1-(4-hydroxyiminomethylpyridinium)-3-pyridiniumpropane dibromide--a new nerve agent reactivator.Revealing the importance of linkers in K-series oxime reactivators for tabun-inhibited AChE using quantum chemical, docking and SMD studies.Potency of five structurally different acetylcholinesterase reactivators to reactivate human brain cholinesterases inhibited by cyclosarin.Potency of new structurally different oximes to reactivate cyclosarin-inhibited human brain acetylcholinesterases.New group of xylene linker-containing acetylcholinesterase reactivators as antidotes against the nerve agent cyclosarin.Assessment of DNA-binding affinity of cholinesterase reactivators and electrophoretic determination of their effect on topoisomerase I and II activity.Synthesis of a novel series of non-symmetrical bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase.
P2860

Synthesis of a novel series of bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase.

Item
http://www.wikidata.org/entity/Q46840644
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Synthesis of a novel series of ...... nhibited acetylcholinesterase.
@en
Synthesis of a novel series of ...... nhibited acetylcholinesterase.
@nl
type
label
Synthesis of a novel series of ...... nhibited acetylcholinesterase.
@en
Synthesis of a novel series of ...... nhibited acetylcholinesterase.
@nl
prefLabel
Synthesis of a novel series of ...... nhibited acetylcholinesterase.
@en
Synthesis of a novel series of ...... nhibited acetylcholinesterase.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P698
P356
P1433
P1476
Synthesis of a novel series of ...... inhibited acetylcholinesterase
@en
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P698