CD69 down-modulation and inhibition of thymic egress by short- and long-term selective chemical agonism of sphingosine 1-phosphate receptors.
about
Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotypeFull pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactionsMicroRNA regulation of T-lymphocyte immunity: modulation of molecular networks responsible for T-cell activation, differentiation, and developmentMaturation and migration of murine CD4 single positive thymocytes and thymic emigrantsB lymphocytes exit lymph nodes through cortical lymphatic sinusoids by a mechanism independent of sphingosine-1-phosphate-mediated chemotaxis.The actin-bundling protein L-plastin dissociates CCR7 proximal signaling from CCR7-induced motilityLigand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening.Thymic emigration: when and how T cells leave home.Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists.S1P3 confers differential S1P-induced migration by autoreactive and non-autoreactive immature B cells and is required for normal B-cell development.TNF-α is involved in the abnormal thymocyte migration during experimental Trypanosoma cruzi infection and favors the export of immature cellsSAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1P₄) receptor.Lipid phosphate phosphatase 3 enables efficient thymic egress.Dynamic regulation of miRNA expression in ordered stages of cellular development.Sphingosine 1-phosphate receptor 1 (S1P(1)) upregulation and amelioration of experimental autoimmune encephalomyelitis by an S1P(1) antagonist.T cell-intrinsic S1PR1 regulates endogenous effector T-cell egress dynamics from lymph nodes during infection.The alliance of sphingosine-1-phosphate and its receptors in immunity.The vascular S1P gradient-cellular sources and biological significance.Maturation and emigration of single-positive thymocytes.Thymocytes in Lyve1-CRE/S1pr1f/f Mice Accumulate in the Thymus due to Cell-Intrinsic Loss of Sphingosine-1-Phosphate Receptor Expression.Dissecting the role of the S1P/S1PR axis in health and disease.Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics.Splenic natural killer cell activity in two models of experimental neurodegenerative diseases.A selective sphingosine-1-phosphate receptor 1 agonist SEW-2871 aggravates gastric cancer by recruiting myeloid-derived suppressor cells.Sphingolipid pathway enzymes modulate cell fate and immune responses.Modulation and the Underlying Mechanism of T Cells in Thymus of Mice by Oral Administration of Sodium Fluoride.Role of Natural Killer Cells in Multiple Sclerosis
P2860
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P2860
CD69 down-modulation and inhibition of thymic egress by short- and long-term selective chemical agonism of sphingosine 1-phosphate receptors.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
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2006年學術文章
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name
CD69 down-modulation and inhib ...... ngosine 1-phosphate receptors.
@en
CD69 down-modulation and inhib ...... ngosine 1-phosphate receptors.
@nl
type
label
CD69 down-modulation and inhib ...... ngosine 1-phosphate receptors.
@en
CD69 down-modulation and inhib ...... ngosine 1-phosphate receptors.
@nl
prefLabel
CD69 down-modulation and inhib ...... ngosine 1-phosphate receptors.
@en
CD69 down-modulation and inhib ...... ngosine 1-phosphate receptors.
@nl
P2093
P2860
P356
P1476
CD69 down-modulation and inhib ...... ngosine 1-phosphate receptors.
@en
P2093
Christopher Alfonso
Hugh Rosen
Michael G McHeyzer-Williams
P2860
P304
P356
10.1002/EJI.200535127
P407
P577
2006-01-01T00:00:00Z