Targeting lipid metabolism by the lipoprotein lipase inhibitor orlistat results in apoptosis of B-cell chronic lymphocytic leukemia cells. - Wikidata - awgldk - TriplyDB

Targeting lipid metabolism by the lipoprotein lipase inhibitor orlistat results in apoptosis of B-cell chronic lymphocytic leukemia cells.

Targeting lipid metabolism by the lipoprotein lipase inhibitor orlistat results in apoptosis of B-cell chronic lymphocytic leukemia cells.

http://www.wikidata.org/entity/Q46850551

about

SIRT2 activates G6PD to enhance NADPH production and promote leukaemia cell proliferation Using functional signatures to identify repositioned drugs for breast, myelogenous leukemia and prostate cancer Blockade of fatty acid synthase triggers significant apoptosis in mantle cell lymphoma Lipoprotein lipase in chronic lymphocytic leukemia: function and prognostic implications.Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction A molecular score by quantitative PCR as a new prognostic tool at diagnosis for chronic lymphocytic leukemia patients.The role of adipose tissue and obesity in causing treatment resistance of acute lymphoblastic leukemia.Inhibition of fatty acid metabolism reduces human myeloma cells proliferation.CLL cells respond to B-Cell receptor stimulation with a microRNA/mRNA signature associated with MYC activation and cell cycle progression Lipoprotein lipase links dietary fat to solid tumor cell proliferation.Myelopoietic efficacy of orlistat in murine hosts bearing T cell lymphoma: implication in macrophage differentiation and activation The PPARα agonist fenofibrate suppresses B-cell lymphoma in mice by modulating lipid metabolism.Aberrant LPL Expression, Driven by STAT3, Mediates Free Fatty Acid Metabolism in CLL Cells.Proteins interaction network and modeling of IGVH mutational status in chronic lymphocytic leukemia Development of a Self-Assembled Nanoparticle Formulation of Orlistat, Nano-ORL, with Increased Cytotoxicity against Human Tumor Cell Lines.Mimicking the tumour microenvironment of chronic lymphocytic leukaemia in vitro critically depends on the type of B-cell receptor stimulation.Lipoprotein lipase: a new prognostic factor in chronic lymphocytic leukaemia The prince and the pauper. A tale of anticancer targeted agents.Gene expression profiling reveals differences in microenvironment interaction between patients with chronic lymphocytic leukemia expressing high versus low ZAP70 mRNA Changes in the peripheral blood transcriptome associated with occupational benzene exposure identified by cross-comparison on two microarray platforms.Elimination of chronic lymphocytic leukemia cells in stromal microenvironment by targeting CPT with an antiangina drug perhexiline.Overexpression of the Fas-inhibitory molecule TOSO: a novel antiapoptotic factor in chronic lymphocytic leukemia.Association of Bax Expression and Bcl2/Bax Ratio with Clinical and Molecular Prognostic Markers in Chronic Lymphocytic Leukemia.RNA-based markers as prognostic factors in chronic lymphocytic leukemia.Fatty Acids and Breast Cancer: Make Them on Site or Have Them Delivered.Defective quorum sensing of acute lymphoblastic leukemic cells: evidence of collective behavior of leukemic populations as semi-autonomous aberrant ecosystems.PPARγ as a sensor of lipase activity and a target for the lipase inhibitor orlistat.Lipoprotein Lipase as a Prognostic Marker in Chronic Lymphocytic Leukemia.LPL gene expression is associated with poor prognosis in CLL and closely related to NOTCH1 mutations.Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming.Lipids and Their Effects in Chronic Lymphocytic Leukemia.miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL.Lipoprotein lipase expression in unmutated CLL patients is the consequence of a demethylation process induced by the microenvironment.Chylomicrons stimulate incretin secretion in mouse and human cells.Lipoprotein Lipase Expression in Chronic Lymphocytic Leukemia: New Insights into Leukemic Progression.Ibrutinib inhibits free fatty acid metabolism in chronic lymphocytic leukemia.PPAR-delta promotes survival of chronic lymphocytic leukemia cells in energetically unfavorable conditions.COBLL1, LPL and ZAP70 expression defines prognostic subgroups of chronic lymphocytic leukemia patients with high accuracy and correlates with IGHV mutational status.Chemical Modification and Organelle-Specific Localization of Orlistat-Like Natural-Product-Based Probes

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P2860

Targeting lipid metabolism by the lipoprotein lipase inhibitor orlistat results in apoptosis of B-cell chronic lymphocytic leukemia cells.

http://www.wikidata.org/entity/Q46850551

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Debey S

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P2860

Gene ontology: tool for the unification of biology

Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1)

Differentially expressed late constituents of the epidermal cornified envelope

Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities

Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells

Human group IVC phospholipase A2 (cPLA2gamma). Roles in the membrane remodeling and activation induced by oxidative stress

Cytoplasmic phospholipase A2 levels correlate with apoptosis in human colon tumorigenesis

A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2

Orlistat: a review of its use in the management of obesity

Phospholipase D2 acts as an essential adaptor protein in the activation of Syk in antigen-stimulated mast cells

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585-592

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10.1038/SJ.LEU.2405058

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Joachim Schultze

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