Free-energy simulations and experiments reveal long-range electrostatic interactions and substrate-assisted specificity in an aminoacyl-tRNA synthetase.
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A single residue in leucyl-tRNA synthetase affecting amino acid specificity and tRNA aminoacylationMD Simulations of tRNA and Aminoacyl-tRNA Synthetases: Dynamics, Folding, Binding, and AllosteryRational approaches to improving selectivity in drug designTetracycline-tet repressor binding specificity: insights from experiments and simulations.Engineering thermal stability of L-asparaginase by in vitro directed evolution.Species specificity of the complement inhibitor compstatin investigated by all-atom molecular dynamics simulationsRedesigning the stereospecificity of tyrosyl-tRNA synthetase.Structural states of the flexible catalytic loop of M. tuberculosis tyrosyl-tRNA synthetase in different enzyme-substrate complexes.Free energy simulations of a GTPase: GTP and GDP binding to archaeal initiation factor 2.A molecular mechanics model for imatinib and imatinib:kinase binding.Probing electrostatic interactions and ligand binding in aspartyl-tRNA synthetase through site-directed mutagenesis and computer simulations.Ammonium scanning in an enzyme active site. The chiral specificity of aspartyl-tRNA synthetase.Computational protein design with a generalized Born solvent model: application to Asparaginyl-tRNA synthetase.Protein:Ligand binding free energies: A stringent test for computational protein designMolecular Dynamics Simulations Show That Bound Mg2+Contributes to Amino Acid and Aminoacyl Adenylate Binding Specificity in Aspartyl-tRNA Synthetase through Long Range Electrostatic InteractionsAn atomistic model for simulations of nilotinib and nilotinib/kinase binding
P2860
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P2860
Free-energy simulations and experiments reveal long-range electrostatic interactions and substrate-assisted specificity in an aminoacyl-tRNA synthetase.
description
2006 nî lūn-bûn
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2006年の論文
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2006年学术文章
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name
Free-energy simulations and ex ...... an aminoacyl-tRNA synthetase.
@en
Free-energy simulations and ex ...... an aminoacyl-tRNA synthetase.
@nl
type
label
Free-energy simulations and ex ...... an aminoacyl-tRNA synthetase.
@en
Free-energy simulations and ex ...... an aminoacyl-tRNA synthetase.
@nl
prefLabel
Free-energy simulations and ex ...... an aminoacyl-tRNA synthetase.
@en
Free-energy simulations and ex ...... an aminoacyl-tRNA synthetase.
@nl
P2860
P356
P1433
P1476
Free-energy simulations and ex ...... an aminoacyl-tRNA synthetase.
@en
P2093
Pierre Plateau
P2860
P304
P356
10.1002/CBIC.200500364
P577
2006-02-01T00:00:00Z