Thermodynamic characterization of substrate and inhibitor binding to Trypanosoma brucei 6-phosphogluconate dehydrogenase.

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Essential multimeric enzymes in kinetoplastid parasites: A host of potentially druggable protein-protein interactions.A survey of the year 2007 literature on applications of isothermal titration calorimetry.6-Phosphogluconate dehydrogenase mechanism: evidence for allosteric modulation by substrate.

P2860

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P2860

Thermodynamic characterization of substrate and inhibitor binding to Trypanosoma brucei 6-phosphogluconate dehydrogenase.

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2007 nî lūn-bûn

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年學術文章

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2007年學術文章

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name

Thermodynamic characterization ...... hosphogluconate dehydrogenase.

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Thermodynamic characterization ...... hosphogluconate dehydrogenase.

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type

Item

label

Thermodynamic characterization ...... hosphogluconate dehydrogenase.

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Thermodynamic characterization ...... hosphogluconate dehydrogenase.

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Thermodynamic characterization ...... hosphogluconate dehydrogenase.

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Thermodynamic characterization ...... hosphogluconate dehydrogenase.

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P1476

Thermodynamic characterization ...... hosphogluconate dehydrogenase.

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P2093

Franco Dallocchio

http://www.w3.org/2001/XMLSchema#string

Katy Montin

http://www.w3.org/2001/XMLSchema#string

Stefania Hanau

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P2860

Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates

Compensating enthalpic and entropic changes hinder binding affinity optimization

Crystallographic study of coenzyme, coenzyme analogue and substrate binding in 6-phosphogluconate dehydrogenase: implications for NADP specificity and the enzyme mechanism

A 2.8 A resolution structure of 6-phosphogluconate dehydrogenase from the protozoan parasite Trypanosoma brucei: comparison with the sheep enzyme accounts for differences in activity with coenzyme and substrate analogues

6-Phosphogluconate dehydrogenase: the mechanism of action investigated by a comparison of the enzyme from different species

Half-site reactivity in 6-phosphogluconate dehydrogenase from human erythrocytes

6-phosphogluconate dehydrogenase: a target for drugs in African trypanosomes.

Synthesis and biological evaluation of phosphate prodrugs of 4-phospho-D-erythronohydroxamic acid, an inhibitor of 6-phosphogluconate dehydrogenase.

Control of rabbit liver fructose-1, 6-diphosphatase activity by magnesium ions.

The stabilization by a coenzyme analog of a conformational change induced by substrate in 6-phosphogluconate dehydrogenase.

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6426-6435

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scholarly article

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10.1111/J.1742-4658.2007.06160.X

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English

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274

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Carlo Cervellati

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2007-11-15T00:00:00Z

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5826302

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18021252

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P921

Trypanosoma brucei

Thermodynamic characterization of substrate and inhibitor binding to Trypanosoma brucei 6-phosphogluconate dehydrogenase.

about

P2860

P2860

Thermodynamic characterization of substrate and inhibitor binding to Trypanosoma brucei 6-phosphogluconate dehydrogenase.

description

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type

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P1433

P1476

P2093

P2860

P304

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P356

P407

P433

P478

P50

P577

P5875

P698

P921

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P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P5875

P698

P921