The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation.
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Nonenantioselectivity property of human deoxycytidine kinase explained by structures of the enzyme in complex with L- and D-nucleosidesStructural basis for substrate promiscuity of dCKElucidation of different binding modes of purine nucleosides to human deoxycytidine kinaseSystematic exploration of active site mutations on human deoxycytidine kinase substrate specificityCurrent status of older and new purine nucleoside analogues in the treatment of lymphoproliferative diseases.Development of gene therapy in association with clinically used cytotoxic deoxynucleoside analogues.New insights into the synergism of nucleoside analogs with radiotherapyDevelopment of an antitumor adenosine analog, 3''-ethynyladenosine.Reprofiling of full-length phosphonated carbocyclic 2'-oxa-3'-aza-nucleosides toward antiproliferative agents: Synthesis, antiproliferative activity, and molecular docking study.
P2860
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P2860
The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation.
description
2006 nî lūn-bûn
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2006年の論文
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2006年学术文章
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2006年学术文章
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name
The structure of human deoxycy ...... ctions for prodrug activation.
@en
The structure of human deoxycy ...... ctions for prodrug activation.
@nl
type
label
The structure of human deoxycy ...... ctions for prodrug activation.
@en
The structure of human deoxycy ...... ctions for prodrug activation.
@nl
prefLabel
The structure of human deoxycy ...... ctions for prodrug activation.
@en
The structure of human deoxycy ...... ctions for prodrug activation.
@nl
P1476
The structure of human deoxycy ...... ctions for prodrug activation.
@en
P2093
John A Secrist
P304
P356
10.1107/S0907444905034293
P577
2006-01-18T00:00:00Z